Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide.
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Overview of base excision repair biochemistryEmerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical exampleAag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1DNA Polymerases λ and β: The Double-Edged Swords of DNA RepairDNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancerMethylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatinNSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer CellsIdentification of functionally methylated regions based on discriminant analysis through integrating methylation and gene expression data.Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells.The many functions of APE1/Ref-1: not only a DNA repair enzymeDesign and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1).Redox regulation of DNA repair: implications for human health and cancer therapeutic development.APNG as a prognostic marker in patients with glioblastoma.Folate deficiency provides protection against colon carcinogenesis in DNA polymerase beta haploinsufficient miceSmall molecule inhibitors of DNA repair nuclease activities of APE1.Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1.Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repairN-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomideLeveraging metabolomics to assess the next generation of temozolomide-based therapeutic approaches for glioblastomasImpact of APE1/Ref-1 redox inhibition on pancreatic tumor growthAlkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patientsRemoval of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair.Aberrant expression of N-methylpurine-DNA glycosylase influences patient survival in malignant gliomas.APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.Nucleotide excision repair deficiency increases levels of acrolein-derived cyclic DNA adduct and sensitizes cells to apoptosis induced by docosahexaenoic acid and acrolein.S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity.DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents.Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis.Downregulation of hPMC2 imparts chemotherapeutic sensitivity to alkylating agents in breast cancer cellsTumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growthBalancing repair and tolerance of DNA damage caused by alkylating agentsRole of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1Inhibiting the DNA damage response as a therapeutic manoeuvre in cancer.DNA repair proteins as molecular targets for cancer therapeutics.Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress.
P2860
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P2860
Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Manipulation of base excision ...... alkylating agent temozolomide.
@en
type
label
Manipulation of base excision ...... alkylating agent temozolomide.
@en
prefLabel
Manipulation of base excision ...... alkylating agent temozolomide.
@en
P2093
P1476
Manipulation of base excision ...... alkylating agent temozolomide
@en
P2093
Mark R Kelley
Martin L Smith
P304
P356
10.1158/1078-0432.CCR-06-1920
P407
P577
2007-01-01T00:00:00Z