about
Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion.The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complexBasic4Cseq: an R/Bioconductor package for analyzing 4C-seq data.Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia.Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy.Transcription factors in myeloid development: balancing differentiation with transformation.Effect of transcription-factor concentrations on leukemic stem cells.Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.Chromatin dynamics during differentiation of myeloid cells.Epigenetic control of hematopoiesis: the PU.1 chromatin connection.Macrophage development from HSCs requires PU.1-coordinated microRNA expression.Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance.DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment.Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.Temporal auto-regulation during human PU.1 locus SubTAD formationHematopoietic stem cell and multilineage defects generated by constitutive β-catenin activationUncovering a unique role for DNA methylation in hematopoietic and leukemic stem cellsSafeguard function of PU.1 shapes the inflammatory epigenome of neutrophils
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description
researcher
@en
wetenschapper
@nl
name
Frank Rosenbauer
@en
Frank Rosenbauer
@nl
type
label
Frank Rosenbauer
@en
Frank Rosenbauer
@nl
prefLabel
Frank Rosenbauer
@en
Frank Rosenbauer
@nl
P106
P21
P31
P496
0000-0001-7977-9421