Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. - Wikidata - awgldk - TriplyDB

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

http://www.wikidata.org/entity/Q47597394

about

C/EBPα Dysregulation in AML and ALL Metallothionein-1 isoforms and vimentin are direct PU.1 downstream target genes in leukemia cells Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by down-regulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN)Mouse models for radiation-induced cancers Chromatin Dynamics in Lineage Commitment and Cellular Reprogramming PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AML Mouse models for efficacy testing of agents against radiation carcinogenesis—a literature review The selection and function of cell type-specific enhancers Evolved Cellular Mechanisms to Respond to Genotoxic Insults: Implications for Radiation-Induced Hematologic Malignancies Transcription factor GATA-1 and Down syndrome leukemogenesis Inhibition of monocytic differentiation by phosphorylation-deficient Stat1 is associated with impaired expression of Stat2, ICSBP/IRF8 and C/EBPepsilon MOZ is essential for maintenance of hematopoietic stem cells Cell-type-specific activation and repression of PU.1 by a complex of discrete, functionally specialized cis-regulatory elements A novel mode of enhancer evolution: the Tal1 stem cell enhancer recruited a MIR element to specifically boost its activity Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1 Oncogenic pathways of AML1-ETO in acute myeloid leukemia: multifaceted manipulation of marrow maturation.Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop inhibiting Pu.1 expression Systemic inoculation of Escherichia coli causes emergency myelopoiesis in zebrafish larval caudal hematopoietic tissue t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression.Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation Novel insights into the genetic controls of primitive and definitive hematopoiesis from zebrafish models Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.Heritable and lineage-specific gene knockdown in zebrafish embryo Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.Frequency of acute myeloid leukaemia-associated mouse chromosome 2 deletions in X-ray exposed immature haematopoietic progenitors and stem cells.Hematopoietic stem cells and retroviral infection.A two-mutation model of radiation-induced acute myeloid leukemia using historical mouse data.Copy-neutral loss of heterozygosity is prevalent and a late event in the pathogenesis of FLT3/ITD AML Potential autoregulation of transcription factor PU.1 by an upstream regulatory element Genome organizing function of SATB1 in tumor progression.Ski can negatively regulates macrophage differentiation through its interaction with PU.1.Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia.miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.A large gene network in immature erythroid cells is controlled by the myeloid and B cell transcriptional regulator PU.1.MicroRNA genes preferentially expressed in dendritic cells contain sites for conserved transcription factor binding motifs in their promoters.

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Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

http://www.wikidata.org/entity/Q47597394

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

Acute myeloid leukemia induced ...... ic transcription factor, PU.1.

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Acute myeloid leukemia induced ...... ic transcription factor, PU.1.

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type

label

Acute myeloid leukemia induced ...... ic transcription factor, PU.1.

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Acute myeloid leukemia induced ...... ic transcription factor, PU.1.

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Acute myeloid leukemia induced ...... ic transcription factor, PU.1.

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Acute myeloid leukemia induced ...... ic transcription factor, PU.1.

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Nature Genetics

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Acute myeloid leukemia induced ...... ic transcription factor, PU.1.

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P2093

Hiromi Iwasaki

http://www.w3.org/2001/XMLSchema#string

Jeffery L Kutok

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Katharina Wagner

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Koichi Akashi

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Michelle M Le Beau

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Yutaka Okuno

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P2860

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

Reversible tumorigenesis by MYC in hematopoietic lineages.

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.

AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.

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624-630

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scholarly article

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10.1038/NG1361

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P433

6

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36

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Steven N. Fiering

Frank Rosenbauer

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2004-05-16T00:00:00Z

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8560332

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15146183

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