The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases
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The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 proteinHuman step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicingProtein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing.Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosomeThe 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteinsAn evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2.Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicingThe human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitroSip1, a novel RS domain-containing protein essential for pre-mRNA splicingProteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function predictionEvidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammalsThe 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomesProteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domainCharacterization of U6 snRNA-protein interactions.PSF and p54nrb bind a conserved stem in U5 snRNAMultiple functions of Saccharomyces cerevisiae splicing protein Prp24 in U6 RNA structural rearrangementsA Sm-like protein complex that participates in mRNA degradationStructural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2Yeast pre-mRNA splicing requires a pair of U1 snRNP-associated tetratricopeptide repeat proteins.Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing.Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociationA comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins.Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins.Cbf5p, a potential pseudouridine synthase, and Nhp2p, a putative RNA-binding protein, are present together with Gar1p in all H BOX/ACA-motif snoRNPs and constitute a common bipartite structure.The 100-kda U5 snRNP protein (hPrp28p) contacts the 5' splice site through its ATPase siteFunctional analysis of the U5 snRNA loop 1 in the second catalytic step of yeast pre-mRNA splicing.Molecular identification and interaction assay of the gene (OsUbc13) encoding a ubiquitin-conjugating enzyme in rice.Conserved loop I of U5 small nuclear RNA is dispensable for both catalytic steps of pre-mRNA splicing in HeLa nuclear extracts.The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex.Dominant negative mutants of the yeast splicing factor Prp2 map to a putative cleft region in the helicase domain of DExD/H-box proteins.A novel missense SNRNP200 mutation associated with autosomal dominant retinitis pigmentosa in a Chinese family.A mutation in a methionine tRNA gene suppresses the prp2-1 Ts mutation and causes a pre-mRNA splicing defect in Saccharomyces cerevisiae.Cell cycle abnormalities associated with differential perturbations of the human U5 snRNP associated U5-200kD RNA helicase.Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding.Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish.Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.Functional roles of protein splicing factors.Association of the mammalian helicase MAH with the pre-mRNA splicing complexThe Ski2-family helicase Obelus regulates Crumbs alternative splicing and cell polarity.
P2860
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P2860
The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases
description
1996 nî lūn-bûn
@nan
1996 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
The HeLa 200 kDa U5 snRNP-spec ...... mily of putative RNA helicases
@ast
The HeLa 200 kDa U5 snRNP-spec ...... mily of putative RNA helicases
@en
The HeLa 200 kDa U5 snRNP-spec ...... mily of putative RNA helicases
@en-gb
The HeLa 200 kDa U5 snRNP-spec ...... mily of putative RNA helicases
@nl
type
label
The HeLa 200 kDa U5 snRNP-spec ...... mily of putative RNA helicases
@ast
The HeLa 200 kDa U5 snRNP-spec ...... mily of putative RNA helicases
@en
The HeLa 200 kDa U5 snRNP-spec ...... mily of putative RNA helicases
@en-gb
The HeLa 200 kDa U5 snRNP-spec ...... mily of putative RNA helicases
@nl
prefLabel
The HeLa 200 kDa U5 snRNP-spec ...... mily of putative RNA helicases
@ast
The HeLa 200 kDa U5 snRNP-spec ...... mily of putative RNA helicases
@en
The HeLa 200 kDa U5 snRNP-spec ...... mily of putative RNA helicases
@en-gb
The HeLa 200 kDa U5 snRNP-spec ...... mily of putative RNA helicases
@nl
P2093
P2860
P921
P3181
P1433
P1476
The HeLa 200 kDa U5 snRNP-spec ...... mily of putative RNA helicases
@en
P2093
P2860
P304
P3181
P407
P577
1996-08-01T00:00:00Z