A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing
about
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosomeComparative genomics and evolution of proteins involved in RNA metabolismThe 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomesPrp8 protein: at the heart of the spliceosomeMultiple functions of Saccharomyces cerevisiae splicing protein Prp24 in U6 RNA structural rearrangementsStructure and interactions of the first three RNA recognition motifs of splicing factor prp24The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicingEvidence for a role of Sky1p-mediated phosphorylation in 3' splice site recognition involving both Prp8 and Prp17/Slu4.Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activationMRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation.The Clf1p splicing factor promotes spliceosome assembly through N-terminal tetratricopeptide repeat contacts.Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.Nuclear RNA export in yeast.Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansionSPF30 is an essential human splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome.Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p.Structural requirement of Ntc77 for spliceosome activation and first catalytic step.Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling.Composition of the editing complex of Trypanosoma bruceiOverexpression of USP39 predicts poor prognosis and promotes tumorigenesis of prostate cancer via promoting EGFR mRNA maturation and transcription elongation.A role for ubiquitin in the spliceosome assembly pathway.Sad1 counteracts Brr2-mediated dissociation of U4/U6.U5 in tri-snRNP homeostasis.Putative role of SUMOylation in controlling the activity of deubiquitinating enzymes in cancer.Ubiquitin-specific protease 39 is overexpressed in human lung cancer and promotes tumor cell proliferation in vitro.Lentivirus mediated silencing of ubiquitin specific peptidase 39 inhibits cell proliferation of human hepatocellular carcinoma cells in vitro.Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast.Downregulation of ubiquitin-specific peptidase 39 suppresses the proliferation and induces the apoptosis of human colorectal cancer cells.miR-133a, directly targeted USP39, suppresses cell proliferation and predicts prognosis of gastric cancer.
P2860
Q24337075-AF023DCE-93D7-400C-9860-1976B3DFA195Q24515041-65C8DE84-0CD9-4072-9B31-724A7042BC88Q24534416-EB44DAC2-EBEE-456A-99C9-455EF9D4E9ACQ24537373-B23C03D5-C1F0-4EB8-8F3B-BC7DF3FB68E1Q24548079-8F46F0F4-9FA2-43A3-8E7C-6242CEC1EF3DQ24681912-3A8A8DC3-5794-4AA9-B438-CF8F770FD3EAQ27682659-1D4FFA60-CED7-4701-BD6E-75C89341B7C2Q27930833-C9994EAB-3EBF-4C83-8C8B-58DE92DD1F84Q27935130-B9606D8D-76D7-4312-8367-AA2BA095EB7FQ27938706-55005C04-AF4A-4C07-8A18-29185B2869D0Q27940003-E9F47E69-1CDA-4754-8430-A16F41B6F192Q33556192-5FFC164F-9805-45C9-9A33-B7434117B584Q33665629-05C910D2-0B6B-4335-9062-36B3B193B77BQ33797859-6344FF1C-DE7A-4CB6-B64C-3BB01D0DEAC9Q33944960-610352AB-E5C8-4F2E-99C7-351A068FE124Q34486872-2757A7E4-E093-4A9A-B725-FC6284B67E1EQ34510168-D641D40D-4E5D-4280-B5A2-542231E13166Q34547657-CE25AF8B-9EBC-4061-B89F-8A8CD24CB9D1Q35212972-00307E0B-2F01-4731-B926-6722576CDA9AQ37225467-44498AAC-4E88-4728-8A51-8A1BBA2CF88DQ37332858-D6A2E5FC-2F3E-4062-8459-9205F57EFC32Q37546093-510060AB-33EC-4B33-A6AB-88562CF48886Q38699941-9C75AEF3-8F41-4102-9C32-0C74D61E20DCQ38746245-39EC8A26-A050-4F9A-A7D5-5FEDEAFB60CBQ38885249-FF30823B-DE73-4A75-85D7-40221DA12E9BQ42055576-351BF854-BBC0-427B-8AFE-D7D843944687Q52647713-B5EDD512-BEDC-4C96-8949-CFAF0779A4E7Q55040342-1DDC44FE-79B2-40F4-A370-77635A1C4155
P2860
A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
A novel genetic screen for snR ...... required for pre-mRNA splicing
@ast
A novel genetic screen for snR ...... required for pre-mRNA splicing
@en
A novel genetic screen for snR ...... required for pre-mRNA splicing
@en-gb
A novel genetic screen for snR ...... required for pre-mRNA splicing
@nl
type
label
A novel genetic screen for snR ...... required for pre-mRNA splicing
@ast
A novel genetic screen for snR ...... required for pre-mRNA splicing
@en
A novel genetic screen for snR ...... required for pre-mRNA splicing
@en-gb
A novel genetic screen for snR ...... required for pre-mRNA splicing
@nl
prefLabel
A novel genetic screen for snR ...... required for pre-mRNA splicing
@ast
A novel genetic screen for snR ...... required for pre-mRNA splicing
@en
A novel genetic screen for snR ...... required for pre-mRNA splicing
@en-gb
A novel genetic screen for snR ...... required for pre-mRNA splicing
@nl
P2860
P356
P1476
A novel genetic screen for snR ...... required for pre-mRNA splicing
@en
P2093
P2860
P304
P356
10.1128/MCB.19.3.2008
P407
P577
1999-03-01T00:00:00Z