Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. - Test2 - elhamkhani - TriplyDB

Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p.

Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p.

http://www.wikidata.org/entity/Q34486872

about

Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for Its Function The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6 The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8 Ubiquitin binds to and regulates a subset of SH3 domains Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.Spliceosome Structure and Function Ubiquitin-binding domains The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31.A bird's-eye view of post-translational modifications in the spliceosome and their roles in spliceosome dynamics Specificity of the BRISC deubiquitinating enzyme is not due to selective binding to Lys63-linked polyubiquitin.Prp8, the pivotal protein of the spliceosomal catalytic center, evolved from a retroelement-encoded reverse transcriptase An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation.BRR2a Affects Flowering Time via FLC Splicing Functional roles of protein splicing factors.Rapid, transcript-specific changes in splicing in response to environmental stress.The ubiquitin-proteasome system of Saccharomyces cerevisiae.Spliceosome activation: U4 is the path, stem I is the goal, and Prp8 is the keeper. Let's cheer for the ATPase Brr2!Detailed close-ups and the big picture of spliceosomes The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites.ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8.A role for ubiquitin in the spliceosome assembly pathway.Zinc-dependent interaction between JAB1 and pre-S2 mutant large surface antigen of hepatitis B virus and its implications for viral hepatocarcinogenesis.Polyubiquitin binding and disassembly by deubiquitinating enzymes.COP9 signalosome interacts ATP-dependently with p97/valosin-containing protein (VCP) and controls the ubiquitination status of proteins bound to p97/VCP.Splicing of mRNA precursors: the role of RNAs and proteins in catalysis.The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine.Decoding ubiquitin for mitosis.RNA splicing: a new player in the DNA damage response Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans.A snRNP's ordered path to maturity.Diverse regulation of 3' splice site usage.Functions and regulation of the Brr2 RNA helicase during splicing.The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA.

P2860

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P2860

Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p.

http://www.wikidata.org/entity/Q34486872

description

2006 nî lūn-bûn

@nan

2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Ubiquitin binding by a variant ...... re-mRNA splicing factor Prp8p.

@ast

Ubiquitin binding by a variant ...... re-mRNA splicing factor Prp8p.

@en

Ubiquitin binding by a variant ...... re-mRNA splicing factor Prp8p.

@nl

type

label

Ubiquitin binding by a variant ...... re-mRNA splicing factor Prp8p.

@ast

Ubiquitin binding by a variant ...... re-mRNA splicing factor Prp8p.

@en

Ubiquitin binding by a variant ...... re-mRNA splicing factor Prp8p.

@nl

prefLabel

Ubiquitin binding by a variant ...... re-mRNA splicing factor Prp8p.

@ast

Ubiquitin binding by a variant ...... re-mRNA splicing factor Prp8p.

@en

Ubiquitin binding by a variant ...... re-mRNA splicing factor Prp8p.

@nl

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P1476

Ubiquitin binding by a variant ...... re-mRNA splicing factor Prp8p.

@en

P2093

Alan K Kutach

http://www.w3.org/2001/XMLSchema#string

Amy K Rines

http://www.w3.org/2001/XMLSchema#string

Christine Guthrie

http://www.w3.org/2001/XMLSchema#string

Priya Bellare

http://www.w3.org/2001/XMLSchema#string

P2860

JAMM: a metalloprotease-like zinc site in the proteasome and signalosome

MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function

The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein

A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing

U box proteins as a new family of ubiquitin-protein ligases

A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing

Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast

The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes

Prp8 protein: at the heart of the spliceosome

Mammalian splicing factor SF3a120 represents a new member of the SURP family of proteins and is homologous to the essential splicing factor PRP21p of Saccharomyces cerevisiae.

P304

292-302

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P31

scholarly article

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10.1261/RNA.2152306

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P407

P433

2

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P478

12

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P50

Erik J. Sontheimer

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2006-02-01T00:00:00Z

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P5875

7343580

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P698

16428608

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P932

1370909

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