Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
about
Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant miceHaploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communicationAssociation of synapse-associated protein 90/ postsynaptic density-95-associated protein (SAPAP) with neurofilamentsDynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeletonSPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampusTyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactinReduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum exportInteraction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteinsImportance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapsesProgressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteinsMutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disordersDisruption of the ProSAP2 gene in a t(12;22)(q24.1;q13.3) is associated with the 22q13.3 deletion syndromep38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAPSynaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3The 22q13.3 Deletion Syndrome (Phelan-McDermid Syndrome)Mechanisms of synapse and dendrite maintenance and their disruption in psychiatric and neurodegenerative disordersMultiple rare variants in the etiology of autism spectrum disordersThe postsynaptic density proteins Homer and Shank form a polymeric network structureCast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho.The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cellsMolecular characterisation of the 22q13 deletion syndrome supports the role of haploinsufficiency of SHANK3/PROSAP2 in the major neurological symptomsEffects of environmental enrichment on gene expression in the brainThe role of neuronal complexes in human X-linked brain diseasesCortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex.Composition of the synaptic PSD-95 complexAutism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neuronsEmerging Link between Alzheimer's Disease and Homeostatic Synaptic PlasticityMouse Genetic Models of Human Brain DisordersInduced pluripotent stem cells for modeling neurological disordersBehavioral phenotypes of genetic mouse models of autism.The NMDA receptor complex: a multifunctional machine at the glutamatergic synapseMolecular mechanisms of dendrite stabilityTherapeutic approaches for shankopathiesTwo knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.The Intense World Theory – A Unifying Theory of the Neurobiology of AutismCrystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerizationDiscovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domain
P2860
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P2860
Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Shank, a novel family of posts ...... -95/GKAP complex and cortactin
@ast
Shank, a novel family of posts ...... -95/GKAP complex and cortactin
@en
Shank, a novel family of posts ...... -95/GKAP complex and cortactin
@en-gb
Shank, a novel family of posts ...... -95/GKAP complex and cortactin
@nl
type
label
Shank, a novel family of posts ...... -95/GKAP complex and cortactin
@ast
Shank, a novel family of posts ...... -95/GKAP complex and cortactin
@en
Shank, a novel family of posts ...... -95/GKAP complex and cortactin
@en-gb
Shank, a novel family of posts ...... -95/GKAP complex and cortactin
@nl
prefLabel
Shank, a novel family of posts ...... -95/GKAP complex and cortactin
@ast
Shank, a novel family of posts ...... -95/GKAP complex and cortactin
@en
Shank, a novel family of posts ...... -95/GKAP complex and cortactin
@en-gb
Shank, a novel family of posts ...... -95/GKAP complex and cortactin
@nl
P2093
P3181
P1433
P1476
Shank, a novel family of posts ...... -95/GKAP complex and cortactin
@en
P2093
J Valtschanoff
P F Worley
R J Weinberg
S Naisbitt
P304
P3181
P356
10.1016/S0896-6273(00)80809-0
P407
P50
P577
1999-07-01T00:00:00Z