Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice
about
Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neuronsAltered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism.Connecting the CNTNAP2 Networks with Neurodevelopmental DisordersMice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.Shank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminalsStriatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism.SHANK proteins: roles at the synapse and in autism spectrum disorder.Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding.Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of AutismShank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit.Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID.Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activationIntegrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations.Delineating the Common Biological Pathways Perturbed by ASD's Genetic Etiology: Lessons from Network-Based StudiesLithium as a rescue therapy for regression and catatonia features in two SHANK3 patients with autism spectrum disorder: case reports.Proteogenomic Analysis Identifies a Novel Human SHANK3 Isoform.Reprogramming patient-derived cells to study the epilepsiesPost-transcriptional regulation of SHANK3 expression by microRNAs related to multiple neuropsychiatric disordersMonogenic mouse models of autism spectrum disorders: Common mechanisms and missing links.Shank-cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapsesProteomic Analysis of Post-synaptic Density Fractions from Shank3 Mutant Mice Reveals Brain Region Specific Changes Relevant to Autism Spectrum Disorder.Editorial. New Targets of Medical Treatment in Psychiatric Disorders.Shank synaptic scaffold proteins: keys to understanding the pathogenesis of autism and other synaptic disorders.Phelan McDermid Syndrome: From Genetic Discoveries to Animal Models and Treatment.Behavioural Phenotypes and Neural Circuit Dysfunctions in Mouse Models of Autism Spectrum Disorder.SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndromeAutism spectrum disorder: neuropathology and animal models.SHANK Mutations May Disorder Brain Development.Developmental profiling of ASD-related shank3 transcripts and their differential regulation by valproic acid in zebrafish.SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons.Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function.Activity and circadian rhythm influence synaptic Shank3 protein levels in mice.Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism.Disrupted circuits in mouse models of autism spectrum disorder and intellectual disability.Shank3-deficient thalamocortical neurons show HCN channelopathy and alterations in intrinsic electrical properties.VTA DA neuron excitatory synapses in Shank3 Δex4-9 mouse line.Deficits in the Proline-Rich Synapse-Associated Shank3 Protein in Multiple Neuropsychiatric Disorders.Shank3 mutations and HCN channelopathy: one size does not fit all.Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors.
P2860
Q26269817-A8BBB46F-B7CF-45D6-92F5-84540496FB24Q27318286-F57B80C8-41C1-4206-9E24-C36D4935269BQ28086930-F253AC3A-88FC-45D8-826B-D602663F901CQ28271310-FEA88C00-2934-446D-A5C8-E943E3677AF6Q28271699-46B36FF9-CEDB-4ACE-9D53-AB9E18D4EB17Q30008746-A836BF3F-AE3E-4B46-B182-84744CADE5F0Q30008776-812CC341-1D21-448A-B293-7856A90A5C61Q30008925-EFD2EB5B-0A57-4DF6-87EF-008247B17DA9Q30362074-322D709A-049F-41CD-AD52-077E2B267D00Q30629661-39999933-6452-4CE0-9365-44D90DA9D85AQ30653240-58819BB4-6BE1-494E-AC8C-B487C093DCD1Q30655543-E224C9F4-5AC6-4B32-BA1E-6A8611FD0D11Q33575832-A6C155FA-36F1-421E-BF73-A2311EEF9B60Q33624758-F9716C20-C684-433F-A3BE-1BBB6B9FAD21Q35595665-65B399D8-6D2D-48A0-A282-4D01841D807DQ35723887-F9EE8FBB-05AE-45B5-BD2A-816A64940D01Q35789597-F7C2F100-2768-489B-90A8-ECC58D390DE2Q36286987-DD6A9DC2-0C20-4751-8F1D-A788A708A18CQ36716971-E809339D-E4E1-43D6-9154-B3FFAF0BB5A3Q37223534-6EB043A0-2749-4B26-8951-95C216D2271DQ37639891-821A79A4-73E7-43B2-9EED-E99F32A5689FQ38553202-0672FAAA-C949-4A01-B3BD-DA1994BA0E04Q38580572-F7B71605-9938-4D9A-A66D-96B3C0725D4BQ38583174-137C4189-0CA8-4EEA-BA3A-3AA71D98BA73Q38678071-E3E2ED7A-6076-404D-9EBD-D5FE444B2A5AQ38713471-CADE90E1-C6A9-49FE-BF1A-6CF06C13A7E5Q38724302-C107463E-21F4-417E-9EC9-B74518D61D4EQ39353531-7F830143-DC7F-4131-8EFA-A71737AB7325Q42129705-8895D453-0639-4D27-9E58-B885F54574A5Q42372591-08F4470A-FA75-47F6-9352-9FA6F6FC536DQ46766704-624331AE-8E69-4B93-8D11-2B37820E0A62Q47136858-C84309F6-12A7-4C44-B623-386CA2774D4EQ47844244-86CA8B12-BC02-4A97-9A79-4B198B7E5595Q47861305-6626A3EF-BAF2-4C1C-812E-A4911CC9D799Q47924863-DA69DE2D-DBDD-4743-A63D-43057C536AFCQ48255997-EC44C5EC-F06E-43FB-9B7E-1B97713B8159Q48387384-1CB3A8E3-BE17-4657-A069-37B680361B72Q49965703-A9A40949-9769-431F-A91B-CDCEC467FC7FQ50088735-2AA4E9EF-F029-421A-B78E-94A0C5646CCEQ52560212-0B4A70FE-4CEB-4E0F-8D68-3E92EDD7FAE5
P2860
Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice
description
2014 nî lūn-bûn
@nan
2014 թուականին հրատարակուած գիտական յօդուած
@hyw
2014 թվականին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Transcriptional and functional ...... autism and Shank3 mutant mice
@ast
Transcriptional and functional ...... autism and Shank3 mutant mice
@en
Transcriptional and functional ...... autism and Shank3 mutant mice
@en-gb
Transcriptional and functional ...... autism and Shank3 mutant mice
@nl
type
label
Transcriptional and functional ...... autism and Shank3 mutant mice
@ast
Transcriptional and functional ...... autism and Shank3 mutant mice
@en
Transcriptional and functional ...... autism and Shank3 mutant mice
@en-gb
Transcriptional and functional ...... autism and Shank3 mutant mice
@nl
prefLabel
Transcriptional and functional ...... autism and Shank3 mutant mice
@ast
Transcriptional and functional ...... autism and Shank3 mutant mice
@en
Transcriptional and functional ...... autism and Shank3 mutant mice
@en-gb
Transcriptional and functional ...... autism and Shank3 mutant mice
@nl
P2093
P2860
P3181
P356
P1433
P1476
Transcriptional and functional ...... autism and Shank3 mutant mice
@en
P2093
Alexandra L Bey
Xiaoming Wang
Yong-Hui Jiang
Yoonji Lee
P2860
P2888
P3181
P356
10.1186/2040-2392-5-30
P407
P577
2014-01-01T00:00:00Z
P5875
P6179
1051616448