Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
about
Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant miceMeta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairmentsImportance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapsesAutistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor functionAutism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neuronsNeuropathological Mechanisms of Seizures in Autism Spectrum DisorderInduced pluripotent stem cells for modeling neurological disordersPrefrontal Cortex and Social Cognition in Mouse and ManBehavioral phenotypes of genetic mouse models of autism.The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disordersModeling psychiatric disorders for developing effective treatmentsExcitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum DisordersCellular and synaptic network defects in autismThe molecular basis of cognitive deficits in pervasive developmental disordersLateral organization of the postsynaptic densityTherapeutic approaches for shankopathiesBehavioral and Neuroanatomical Phenotypes in Mouse Models of AutismTwo knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B(-/-) miceCoronin 1 regulates cognition and behavior through modulation of cAMP/protein kinase A signalingAltered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism.Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.Neural selectivity for communicative auditory signals in Phelan-McDermid syndrome.A novel anesthesia regime enables neurofunctional studies and imaging genetics across mouse strainsNegative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.Genetic aspects of autism spectrum disorders: insights from animal modelsActin-Dependent Alterations of Dendritic Spine Morphology in ShankopathiesAdvancing the understanding of autism disease mechanisms through geneticsNeuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorderNeurobiology of social behavior abnormalities in autism and Williams syndromeA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.The Use of Induced Pluripotent Stem Cell Technology to Advance Autism Research and TreatmentCommon mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disordersDiscovery of Rare Mutations in Autism: Elucidating Neurodevelopmental MechanismsDeletion of α-neurexin II results in autism-related behaviors in micePhelan-McDermid syndrome: a review of the literature and practice parameters for medical assessment and monitoringAutistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disordersAdult restoration of Shank3 expression rescues selective autistic-like phenotypes
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P2860
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
@ast
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
@en
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
@nl
type
label
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
@ast
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
@en
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
@nl
prefLabel
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
@ast
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
@en
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
@nl
P2093
P2860
P921
P3181
P356
P1476
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
@en
P2093
Adam C Roberts
Arthur L Beaudet
Benjamin D Philpot
Caroline J Kim
Danielle Bousquet-Moore
H Shawn Je
Isabel Lorenzo
Janet Berrios
Jennifer S Colvin
P2860
P304
P3181
P356
10.1093/HMG/DDR212
P407
P577
2011-08-01T00:00:00Z