Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses
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Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant miceAutistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor functionClinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders.Therapeutic approaches for shankopathiesTwo knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B(-/-) micePharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disordersUsing mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactionsShank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanismUsing Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autismZinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3.CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency.Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of AutismSelective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.Absence of strong strain effects in behavioral analyses of Shank3-deficient miceDevelopmental vulnerability of synapses and circuits associated with neuropsychiatric disorders.Loss of predominant Shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission.Translational animal models of autism and neurodevelopmental disorders.Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant miceTrans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activationSHANK3 controls maturation of social reward circuits in the VTAThe Shank3 Interaction Partner ProSAPiP1 Regulates Postsynaptic SPAR Levels and the Maturation of Dendritic Spines in Hippocampal Neurons.Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling.Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and AutismGenetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin-expressing inhibitory interneurons.Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator.Autism spectrum disorder and epilepsy: Disorders with a shared biology.Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits.Environmental factors in autism.Gene dysregulation is restored in the Parkinson's disease MPTP neurotoxic mice model upon treatment of the therapeutic drug Cu(II)(atsm).Is autism a disease of the cerebellum? An integration of clinical and pre-clinical research.Zinc Stabilizes Shank3 at the Postsynaptic Density of Hippocampal Synapses.Shank Modulates Postsynaptic Wnt Signaling to Regulate Synaptic Development.Fear extinction induces mGluR5-mediated synaptic and intrinsic plasticity in infralimbic neurons.Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling.Modulation of behavior by scaffolding proteins of the post-synaptic density.Shank-cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapses
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Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses
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2011 nî lūn-bûn
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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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Importance of Shank3 protein i ...... sion and signaling at synapses
@ast
Importance of Shank3 protein i ...... sion and signaling at synapses
@en
Importance of Shank3 protein i ...... sion and signaling at synapses
@en-gb
Importance of Shank3 protein i ...... sion and signaling at synapses
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Importance of Shank3 protein i ...... sion and signaling at synapses
@ast
Importance of Shank3 protein i ...... sion and signaling at synapses
@en
Importance of Shank3 protein i ...... sion and signaling at synapses
@en-gb
Importance of Shank3 protein i ...... sion and signaling at synapses
@nl
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Importance of Shank3 protein i ...... sion and signaling at synapses
@ast
Importance of Shank3 protein i ...... sion and signaling at synapses
@en
Importance of Shank3 protein i ...... sion and signaling at synapses
@en-gb
Importance of Shank3 protein i ...... sion and signaling at synapses
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Importance of Shank3 protein i ...... sion and signaling at synapses
@en
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Cinzia Vicidomini
Elena Dvoretskova
Francesca Rossi
Michael Schoen
Michela Chiappalone
Tobias M Böckers
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P304
P3181
P356
10.1074/JBC.M111.258384
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P577
2011-10-07T00:00:00Z