Purification and cloning of amyloid precursor protein beta-secretase from human brain
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The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease miceTransthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?A mutation in APP protects against Alzheimer’s disease and age-related cognitive declinePAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinA new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolismBinding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavageGGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β productionSorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processingFlotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sortingThe Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motifBiological markers of amyloid beta-related mechanisms in Alzheimer's diseaseAmyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patientsSignaling effect of amyloid-beta(42) on the processing of AbetaPPBACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor proteinThe amyloid precursor protein: beyond amyloidPro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pHStepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugsAmyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET ImagingG Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRsHypertension and Dementia: Epidemiological and Experimental Evidence Revealing a Detrimental RelationshipThe role of APP and BACE1 trafficking in APP processing and amyloid-β generationTrafficking regulation of proteins in Alzheimer's diseaseInsights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's diseaseToward the structure of presenilin/γ-secretase and presenilin homologsComputational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β -SecretaseThe multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foesStructure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolutionCrystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid Protein ProductionDiscovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer DiseaseFlexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulationsFamilial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage siteRab GTPases, membrane trafficking and diseasesAPP processing in Alzheimer's diseaseDevelopment and Structural Modification of BACE1 InhibitorsProteomic Substrate Identification for Membrane Proteases in the BrainPMEL Amyloid Fibril Formation: The Bright Steps of PigmentationThe beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocationβ-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's diseaseProteolytic processing of Alzheimer's β-amyloid precursor protein
P2860
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P2860
Purification and cloning of amyloid precursor protein beta-secretase from human brain
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Purification and cloning of amyloid precursor protein beta-secretase from human brain
@ast
Purification and cloning of amyloid precursor protein beta-secretase from human brain
@en
Purification and cloning of amyloid precursor protein beta-secretase from human brain
@en-gb
Purification and cloning of amyloid precursor protein beta-secretase from human brain
@nl
type
label
Purification and cloning of amyloid precursor protein beta-secretase from human brain
@ast
Purification and cloning of amyloid precursor protein beta-secretase from human brain
@en
Purification and cloning of amyloid precursor protein beta-secretase from human brain
@en-gb
Purification and cloning of amyloid precursor protein beta-secretase from human brain
@nl
prefLabel
Purification and cloning of amyloid precursor protein beta-secretase from human brain
@ast
Purification and cloning of amyloid precursor protein beta-secretase from human brain
@en
Purification and cloning of amyloid precursor protein beta-secretase from human brain
@en-gb
Purification and cloning of amyloid precursor protein beta-secretase from human brain
@nl
P2093
P3181
P356
P1433
P1476
Purification and cloning of amyloid precursor protein beta-secretase from human brain
@en
P2093
I Lieberburg
P2888
P304
P3181
P356
10.1038/990114
P407
P577
1999-12-02T00:00:00Z
P6179
1024612894