A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics
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Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoterGeneral cell-binding activity of intramolecular G-quadruplexes with parallel structureDownregulation of oncogenic RAS and c-Myc expression in MOLT-4 leukaemia cells by a salicylaldehyde semicarbazone copper(II) complexA core extended naphtalene diimide G-quadruplex ligand potently inhibits herpes simplex virus 1 replicationInhibition of cancer cell migration and invasion through suppressing the Wnt1-mediating signal pathway by G-quadruplex structure stabilizersMolecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expressionThe major G-quadruplex formed in the human BCL-2 proximal promoter adopts a parallel structure with a 13-nt loop in K+ solutionTargeting G-quadruplexes in gene promoters: a novel anticancer strategy?Making sense of G-quadruplex and i-motif functions in oncogene promoters.Targeting MYC Expression through G-Quadruplexes.Possible regulatory roles of promoter g-quadruplexes in cardiac function-related genes - human TnIc as a model.Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes.Aptamer selection based on G4-forming promoter region.Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexesMapping the sequences of potential guanine quadruplex motifs.Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter regionSequencing and G-quadruplex folding of the canine proto-oncogene KIT promoter region: might dog be used as a model for human disease?A Personal History of Quadruplex-Small Molecule Targeting.Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models.Separation of Quadruplex Polymorphism in DNA Sequences by Reversed-Phase Chromatography.Sequence, stability, and structure of G-quadruplexes and their interactions with drugsA new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topologyInduction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activityTargeting DNA G-quadruplex structures with peptide nucleic acids.KIT over-expression by p55PIK-PI3K leads to Imatinib-resistance in patients with gastrointestinal stromal tumorsA novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes.G-register exchange dynamics in guanine quadruplexes.DNA secondary structures: stability and function of G-quadruplex structures.Polymorphism and resolution of oncogene promoter quadruplex-forming sequences.Structural basis of sodium-potassium exchange of a human telomeric DNA quadruplex without topological conversion.Conformational changes of non-B DNA.Oligonucleotide-templated chemical reactions: pushing the boundaries of a nature-inspired process.High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation.Insight into G-DNA structural polymorphism and folding from sequence and loop connectivity through free energy analysis.Resolution of quadruplex polymorphism by size-exclusion chromatography.Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug-like molecules.Co-existence of Distinct Supramolecular Assemblies in Solution and in the Solid State.RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms.Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines.Variable-temperature size exclusion chromatography for the study of the structural changes in g-quadruplex.
P2860
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P2860
A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A G-Rich Sequence within the c ...... g Asymmetric G-Tetrad Dynamics
@ast
A G-Rich Sequence within the c ...... g Asymmetric G-Tetrad Dynamics
@en
A G-Rich Sequence within the c ...... g Asymmetric G-Tetrad Dynamics
@nl
type
label
A G-Rich Sequence within the c ...... g Asymmetric G-Tetrad Dynamics
@ast
A G-Rich Sequence within the c ...... g Asymmetric G-Tetrad Dynamics
@en
A G-Rich Sequence within the c ...... g Asymmetric G-Tetrad Dynamics
@nl
altLabel
A G-Rich Sequence within thec- ...... g Asymmetric G-Tetrad Dynamics
@en
prefLabel
A G-Rich Sequence within the c ...... g Asymmetric G-Tetrad Dynamics
@ast
A G-Rich Sequence within the c ...... g Asymmetric G-Tetrad Dynamics
@en
A G-Rich Sequence within the c ...... g Asymmetric G-Tetrad Dynamics
@nl
P2093
P2860
P50
P3181
P356
P1476
A G-Rich Sequence within the c ...... g Asymmetric G-Tetrad Dynamics
@en
P2093
Anthony P Reszka
Peter Varnai
Shankar Balasubramanian
P2860
P304
P3181
P356
10.1021/JA904007P
P407
P577
2009-09-23T00:00:00Z