Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP - Test2 - elhamkhani - TriplyDB

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

http://www.wikidata.org/entity/Q22251081

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The antidiabetic gutsy role of metformin uncovered?Repurposing metformin: an old drug with new tricks in its binding pockets Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase Molecular mechanism of action of metformin: old or new insights?The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK.Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agents Current understanding of metformin effect on the control of hyperglycemia in diabetes New mechanisms of metformin action: Focusing on mitochondria and the gut Therapeutic Use of Metformin in Prediabetes and Diabetes Prevention Pancreatic α-Cell Dysfunction in Type 2 Diabetes: Old Kids on the Block Something old, something new and something very old: drugs for treating type 2 diabetes Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium AMPK: a target for drugs and natural products with effects on both diabetes and cancer New promises for metformin: advances in the understanding of its mechanisms of action Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease Protection against the Metabolic Syndrome by Guar Gum-Derived Short-Chain Fatty Acids Depends on Peroxisome Proliferator-Activated Receptor γ and Glucagon-Like Peptide-1 Adenosine monophosphate-activated protein kinase-based classification of diabetes pharmacotherapy Metformin and metabolic diseases: a focus on hepatic aspects The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery Metformin, a diabetes drug, eliminates tumor-initiating hepatocellular carcinoma cells Berberine promotes glucose consumption independently of AMP-activated protein kinase activation Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells The 5'-AMP-Activated Protein Kinase (AMPK) Is Involved in the Augmentation of Antioxidant Defenses in Cryopreserved Chicken Sperm Genomic Characterization of Metformin Hepatic Response Treatment of nonalcoholic fatty liver disease: role of AMPK.Metformin improves glucose effectiveness, not insulin sensitivity: predicting treatment response in women with polycystic ovary syndrome in an open-label, interventional study.Gs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP Signaling Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation.Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis Antioxidant and Anti-Senescence Effect of Metformin on Mouse Olfactory Ensheathing Cells (mOECs) May Be Associated with Increased Brain-Derived Neurotrophic Factor Levels-An Ex Vivo Study.EJE PRIZE 2017: Hypothalamic AMPK: a golden target against obesity?Dissecting the role of AMP-activated protein kinase in human diseases.Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action Convergence of IPMK and LKB1-AMPK signaling pathways on metformin action.AMPK activation: a therapeutic target for type 2 diabetes?Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus.High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice.Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK).

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P2860

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

http://www.wikidata.org/entity/Q22251081

description

2013 nî lūn-bûn

@nan

2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի փետրվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

@ast

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

@en

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

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type

label

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

@ast

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

@en

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

@en-gb

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

@nl

prefLabel

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

@ast

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

@en

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

@en

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Jianxin Xie

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Qingwei Chu

http://www.w3.org/2001/XMLSchema#string

Russell A Miller

http://www.w3.org/2001/XMLSchema#string

P2860

Role of AMP-activated protein kinase in mechanism of metformin action

Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

Cation and structural requirements for P site-mediated inhibition of adenylate cyclase

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

The 31P NMR visibility of ATP in perfused rat liver remains about 90%, unaffected by changes of metabolic state.

Biochemical methods for detection and measurement of cyclic AMP and adenylyl cyclase activity.

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

Metformin kinetics in healthy subjects and in patients with diabetes mellitus.

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

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256-60

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10.1038/NATURE11808

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7436

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494

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Morris J. Birnbaum

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2013-02-14T00:00:00Z

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234070210

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1016730403

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23292513

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3573218

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