Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase - Test2 - elhamkhani - TriplyDB

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

http://www.wikidata.org/entity/Q22251079

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Repurposing metformin: an old drug with new tricks in its binding pockets Novel drugs that target the metabolic reprogramming in renal cell cancer The treatment of type 2 diabetes in the presence of renal impairment: what we should know about newer therapies Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules Nuclear receptors and AMPK: can exercise mimetics cure diabetes?Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agents Sodium-glucose cotransporter-2 inhibitor combination therapy to optimize glycemic control and tolerability in patients with type 2 diabetes: focus on dapagliflozin-metformin Current understanding of metformin effect on the control of hyperglycemia in diabetes New mechanisms of metformin action: Focusing on mitochondria and the gut Old drug, new trick: repurposing metformin for gynecologic cancers?Metformin in women with type 2 diabetes in pregnancy (MiTy): a multi-center randomized controlled trial.Diabetes propels the risk for cardiovascular disease: sweet monocytes becoming aggressive?Metformin and the gastrointestinal tract Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes Medium Renewal Blocks Anti-Proliferative Effects of Metformin in Cultured MDA-MB-231 Breast Cancer Cells Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons MATE2 Expression Is Associated with Cancer Cell Response to Metformin 2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications Pharmacogenomics in type 2 diabetes: oral antidiabetic drugs.Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus.Exercise training plus metformin, but not exercise training alone, decreases insulin production and increases insulin clearance in adults with prediabetes.Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A).Hepatic glucose and lipid metabolism.Combination of metformin and curcumin targets breast cancer in mice by angiogenesis inhibition, immune system modulation and induction of p53 independent apoptosis.Dissecting the role of AMP-activated protein kinase in human diseases.To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents Metformin intake associates with better cognitive function in patients with Huntington's disease.Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK).Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium.Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice.Intake of St John's wort improves the glucose tolerance in healthy subjects who ingest metformin compared with metformin alone.Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy Four key questions about metformin and cancer.Transcriptomic analysis of human polarized macrophages: more than one role of alternative activation?Addition of a Gastrointestinal Microbiome Modulator to Metformin Improves Metformin Tolerance and Fasting Glucose Levels Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study.

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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

http://www.wikidata.org/entity/Q22251079

description

2014 nî lūn-bûn

@nan

2014 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

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name

Metformin suppresses gluconeog ...... glycerophosphate dehydrogenase

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Metformin suppresses gluconeog ...... glycerophosphate dehydrogenase

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Metformin suppresses gluconeog ...... glycerophosphate dehydrogenase

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Metformin suppresses gluconeog ...... glycerophosphate dehydrogenase

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type

label

Metformin suppresses gluconeog ...... glycerophosphate dehydrogenase

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Metformin suppresses gluconeog ...... glycerophosphate dehydrogenase

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Metformin suppresses gluconeog ...... glycerophosphate dehydrogenase

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Metformin suppresses gluconeog ...... glycerophosphate dehydrogenase

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prefLabel

Metformin suppresses gluconeog ...... glycerophosphate dehydrogenase

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Metformin suppresses gluconeog ...... glycerophosphate dehydrogenase

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Metformin suppresses gluconeog ...... glycerophosphate dehydrogenase

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Metformin suppresses gluconeog ...... glycerophosphate dehydrogenase

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Metformin suppresses gluconeog ...... glycerophosphate dehydrogenase

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Anila K Madiraju

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Brett J Prigaro

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Demetrios T Braddock

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Derek M Erion

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Gary W Cline

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Hui-Young Lee

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Joao-Paulo Camporez

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John L Wood

http://www.w3.org/2001/XMLSchema#string

Michael J MacDonald

http://www.w3.org/2001/XMLSchema#string

Richard G Kibbey

http://www.w3.org/2001/XMLSchema#string

P2860

Mechanism by which metformin reduces glucose production in type 2 diabetes

Role of AMP-activated protein kinase in mechanism of metformin action

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

Role of glycerol 3-phosphate dehydrogenase in glyceride metabolism. Effect of diet on enzyme activities in chicken liver

The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver

Structure of alpha-glycerophosphate oxidase from Streptococcus sp.: a template for the mitochondrial alpha-glycerophosphate dehydrogenase

Mouse lacking NAD+-linked glycerol phosphate dehydrogenase has normal pancreatic beta cell function but abnormal metabolite pattern in skeletal muscle

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.

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542-546

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scholarly article

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48495

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10.1038/NATURE13270

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7506

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510

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Michael J. Jurczak

Gerald I. Shulman

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2014-05-21T00:00:00Z

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262529290

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1024050118

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24847880

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4074244

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