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Detectable clonal mosaicism and its relationship to aging and cancer

Detectable clonal mosaicism and its relationship to aging and cancer

http://www.wikidata.org/entity/Q23916196

about

Single cell genomics: advances and future perspectives Characterization of large structural genetic mosaicism in human autosome Somatic mosaicism in the human genome Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?The FHIT gene product: tumor suppressor and genome "caretaker"Children's Oncology Group's 2013 blueprint for research: bone tumors Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome New insights into the generation and role of de novo mutations in health and disease Clinical applications of liquid biopsies in gastrointestinal oncology Clonal hematopoiesis in acquired aplastic anemia The hallmarks of aging Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing Variations in brain DNA PeSV-Fisher: identification of somatic and non-somatic structural variants using next generation sequencing data A novel method for detecting uniparental disomy from trio genotypes identifies a significant excess in children with developmental disorders Genome-wide consequences of deleting any single gene Loss of Y Chromosome in Peripheral Blood of Colorectal and Prostate Cancer Patients Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer Sensitive and specific detection of mosaic chromosomal abnormalities using the Parent-of-Origin-based Detection (POD) method Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations Detectable clonal mosaicism from birth to old age and its relationship to cancer Molecular and cytogenetic characterization of expanded B-cell clones from multiclonal versus monoclonal B-cell chronic lymphoproliferative disorders Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis Clinical Correlates of Autosomal Chromosomal Abnormalities in an Electronic Medical Record-Linked Genome-Wide Association Study: A Case Series.Republished: Non-heritable genetics of human disease: spotlight on post-zygotic genetic variation acquired during lifetime Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia Elevated tolerance to aneuploidy in cancer cells: estimating the fitness effects of chromosome number alterations by in silico modelling of somatic genome evolution Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis Detection of clonal blood cells with specific chromosomal abnormalities in the general population A summary of the osteosarcoma banking efforts: a report from the Children's Oncology Group and the QuadW Foundation Age-related clonal hematopoiesis associated with adverse outcomes Mosaic epigenetic dysregulation of ectodermal cells in autism spectrum disorder Changing genetic paradigms: creating next-generation genetic databases as tools to understand the emerging complexities of genotype/phenotype relationships Elimination of unfit cells maintains tissue health and prolongs lifespan Myelodysplastic Syndromes Diagnosis: What Is the Role of Molecular Testing?Age-related mutations associated with clonal hematopoietic expansion and malignancies Ultra-fast local-haplotype variant calling using paired-end DNA-sequencing data reveals somatic mosaicism in tumor and normal blood samples Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution

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Detectable clonal mosaicism and its relationship to aging and cancer

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2012 nî lūn-bûn

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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2012 թվականի հունիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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Detectable clonal mosaicism and its relationship to aging and cancer

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Detectable clonal mosaicism and its relationship to aging and cancer

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Detectable clonal mosaicism and its relationship to aging and cancer

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Detectable clonal mosaicism and its relationship to aging and cancer

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Detectable clonal mosaicism and its relationship to aging and cancer

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Detectable clonal mosaicism and its relationship to aging and cancer

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Detectable clonal mosaicism and its relationship to aging and cancer

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Detectable clonal mosaicism and its relationship to aging and cancer

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Detectable clonal mosaicism and its relationship to aging and cancer

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Detectable clonal mosaicism and its relationship to aging and cancer

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Detectable clonal mosaicism and its relationship to aging and cancer

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Detectable clonal mosaicism and its relationship to aging and cancer

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Nature Genetics

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Detectable clonal mosaicism and its relationship to aging and cancer

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Alan A Arslan

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Alisa M Goldstein

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Alison Johnson

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Alison P Klein

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Amanda Black

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Ana Patiño García

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Ann G Schwartz

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Ann W Hsing

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Annelie Landgren

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Barry I Graubard

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P2860

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

International network of cancer genome projects.

A second generation human haplotype map of over 3.1 million SNPs

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia

A new look at the statistical model identification

Genomic aberrations and survival in chronic lymphocytic leukemia

Mechanisms and consequences of somatic mosaicism in humans

Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia

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20040807

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scholarly article

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10.1038/NG.2270

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6

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44

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Dimitrios Trichopoulos

Edward Giovannucci

David J. Hunter

Nilanjan Chatterjee

Stephen Chanock

Meredith Yeager

Nathaniel Rothman

Manolis Kogevinas

Demetrius Albanes

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2012-06-01T00:00:00Z

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224914056

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1048576872

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National Institute for Occupational Safety and Health

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3372921

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