Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain
about
Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitorsIdentification and characterization of DEDD2, a death effector domain-containing proteinRecruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner HippiReplacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell deathHuntingtin-interacting protein 1-mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterationsExpression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cellsHIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domainsCloning, expression, purification, crystallization and preliminary crystallographic analysis of pseudo death-effector domain of HIPPI, a molecular partner of Huntingtin-interacting protein HIP-1Genetics and neuropathology of Huntington's diseaseCrystal Structure at 2.8 Å of the DLLRKN-containing Coiled-coil Domain of Huntingtin-interacting Protein 1 (HIP1) Reveals a Surface Suitable for Clathrin Light Chain BindingCrystal Structure at 2.8 Å of Huntingtin-Interacting Protein 1 (HIP1) Coiled-Coil Domain Reveals a Charged Surface Suitable for HIP1 Protein Interactor (HIPPI)Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domainActin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chainHuntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survivalNormal huntingtin function: an alternative approach to Huntington's diseaseHuntington's disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcriptionHuntington's diseaseFunctional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's diseaseDeletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitroWild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.Identification of nuclear phosphoproteins as novel tobacco markers in mouse lung tissue following short-term exposure to tobacco smoke.Therapeutic approaches to preventing cell death in Huntington diseaseFunctions of huntingtin in germ layer specification and organogenesis.Use of a cryptic splice site for the expression of huntingtin interacting protein 1 in select normal and neoplastic tissues.Clinical and research advances in Huntington's disease.Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene.An Integrated Bioinformatics and Computational Biology Approach Identifies New BH3-Only Protein CandidatesmiR-196a Ameliorates Cytotoxicity and Cellular Phenotype in Transgenic Huntington's Disease Monkey Neural CellsMolecular mechanisms and potential therapeutical targets in Huntington's disease.The biological function of the Huntingtin protein and its relevance to Huntington's Disease pathologyUnconventional functions for clathrin, ESCRTs, and other endocytic regulators in the cytoskeleton, cell cycle, nucleus, and beyond: links to human disease.Gene Co-Expression Network Analysis Reveals the Correlation Patterns Among Genes in Euryhaline Adaptation of Crassostrea gigas.A link between chromatin condensation mechanisms and Huntington's disease: connecting the dots.Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing.Mutant huntingtin affects the rate of transcription of striatum-specific isoforms of phosphodiesterase 10A.Effect of early embryonic deletion of huntingtin from pyramidal neurons on the development and long-term survival of neurons in cerebral cortex and striatum.McLeod phenotype associated with a XK missense mutation without hematologic, neuromuscular, or cerebral involvement.Disrupted striatal neuron inputs and outputs in Huntington's disease.RNAi-based therapies for Huntington’s disease: delivery challenges and opportunities
P2860
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P2860
Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Huntingtin interacting protein ...... ependent death effector domain
@ast
Huntingtin interacting protein ...... ependent death effector domain
@en
Huntingtin interacting protein ...... ependent death effector domain
@en-gb
Huntingtin interacting protein ...... ependent death effector domain
@nl
type
label
Huntingtin interacting protein ...... ependent death effector domain
@ast
Huntingtin interacting protein ...... ependent death effector domain
@en
Huntingtin interacting protein ...... ependent death effector domain
@en-gb
Huntingtin interacting protein ...... ependent death effector domain
@nl
prefLabel
Huntingtin interacting protein ...... ependent death effector domain
@ast
Huntingtin interacting protein ...... ependent death effector domain
@en
Huntingtin interacting protein ...... ependent death effector domain
@en-gb
Huntingtin interacting protein ...... ependent death effector domain
@nl
P2093
P2860
P921
P3181
P356
P1476
Huntingtin interacting protein ...... ependent death effector domain
@en
P2093
Gervais FG
Gutekunst CA
Nicholson DW
Vaillancourt J
P2860
P304
41299-41308
P3181
P356
10.1074/JBC.M008408200
P407
P577
2000-12-01T00:00:00Z