The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
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Nedd4-2 and the regulation of epithelial sodium transportPhosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expressionProteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cellsRespiratory distress and perinatal lethality in Nedd4-2-deficient miceNedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functionsEpithelial Na(+) channel regulation by cytoplasmic and extracellular factorsUbiquitylation and control of renal Na+ balance and blood pressureUbiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channelVasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting proteinComparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arraysN4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated proteinHECT E3s and human disease.Polymorphism in NEDD4L is associated with increased salt sensitivity, reduced levels of P-renin and increased levels of Nt-proANP.Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control studyIdentification of candidate genes for dyslexia susceptibility on chromosome 18.A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila.Identification of epistatic effects using a protein-protein interaction database.Alternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains.Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertensionNedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells.Nedd4-2 (NEDD4L) controls intracellular Na(+)-mediated activity of voltage-gated sodium channels in primary cortical neurons.Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage.Abnormal regulation of ENaC: syndromes of salt retention and salt wasting by the collecting duct.NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and YPXL late domains.Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport.Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11.The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture.Crystallization and preliminary X-ray diffraction studies of the WW4 domain of the Nedd4-2 ubiquitin-protein ligase.Regulation of ENaC-mediated alveolar fluid clearance by insulin via PI3K/Akt pathway in LPS-induced acute lung injuryParticipation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel.Ndfip2 is a potential regulator of the iron transporter DMT1 in the liverDeubiquitylation regulates activation and proteolytic cleavage of ENaCRegulation of the divalent metal ion transporter via membrane budding.Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response.The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism.The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation.The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels.Regulation of epithelial sodium channel trafficking by ubiquitination.
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P2860
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
description
2001 nî lūn-bûn
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2001 թուականի Մարտին հրատարակուած գիտական յօդուած
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2001 թվականի մարտին հրատարակված գիտական հոդված
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2001年の論文
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年學術文章
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name
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
@ast
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
@en
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
@en-gb
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
@nl
type
label
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
@ast
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
@en
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
@en-gb
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
@nl
prefLabel
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
@ast
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
@en
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
@en-gb
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
@nl
P2860
P3181
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P1476
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.C000906200
P407
P577
2001-03-16T00:00:00Z