The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase
about
MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disordersThe kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation siteEukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivoPhosphorylation of microtubule-associated protein tau by AMPK-related kinasesDirect association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactionsProtein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligaseRegulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylationExploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in DrosophilaTwo novel phosphorylation sites on FKHR that are critical for its nuclear exclusionA genetic cause of Alzheimer disease: mechanistic insights from Down syndromeDevelopment of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1AStructures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate RecognitionThe structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteineEngagement of DYRK2 in proper control for cell divisionDyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitorsRole of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathwayDYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.GSK-3: Functional Insights from Cell Biology and Animal Models.Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in miceDYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort.A role for protein phosphorylation in cytochrome P450 3A4 ubiquitin-dependent proteasomal degradationGreen tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytesMechanisms of tau-induced neurodegeneration.Novel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422.Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body.Plasma DYRK1A as a novel risk factor for Alzheimer's disease.GSK3 takes centre stage more than 20 years after its discovery.Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin.The role of DYRK1A in neurodegenerative diseases.DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndromeDown syndrome--recent progress and future prospects.DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3β on eIF2Bε.What Are the bona fide GSK3 Substrates?Phosphorylation and inactivation of glycogen synthase kinase 3β (GSK3β) by dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)Screening Dyrk1A inhibitors by MALDI-QqQ mass spectrometry: systematic comparison to established radiometric, luminescence, and LC-UV-MS assays.
P2860
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P2860
The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase
description
2001 nî lūn-bûn
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2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
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name
The kinase DYRK phosphorylates ...... nthase kinase 3-priming kinase
@ast
The kinase DYRK phosphorylates ...... nthase kinase 3-priming kinase
@en
The kinase DYRK phosphorylates ...... nthase kinase 3-priming kinase
@en-gb
The kinase DYRK phosphorylates ...... nthase kinase 3-priming kinase
@nl
type
label
The kinase DYRK phosphorylates ...... nthase kinase 3-priming kinase
@ast
The kinase DYRK phosphorylates ...... nthase kinase 3-priming kinase
@en
The kinase DYRK phosphorylates ...... nthase kinase 3-priming kinase
@en-gb
The kinase DYRK phosphorylates ...... nthase kinase 3-priming kinase
@nl
prefLabel
The kinase DYRK phosphorylates ...... nthase kinase 3-priming kinase
@ast
The kinase DYRK phosphorylates ...... nthase kinase 3-priming kinase
@en
The kinase DYRK phosphorylates ...... nthase kinase 3-priming kinase
@en-gb
The kinase DYRK phosphorylates ...... nthase kinase 3-priming kinase
@nl
P2093
P2860
P921
P356
P1433
P1476
The kinase DYRK phosphorylates ...... nthase kinase 3-priming kinase
@en
P2093
P2860
P304
P356
10.1042/BJ3550609
P407
P577
2001-05-01T00:00:00Z