Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors
about
Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaksInvolvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindleThe F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenanceFez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongationTelomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeatsGNL3L stabilizes the TRF1 complex and promotes mitotic transitionThe identification of zebrafish mutants showing alterations in senescence-associated biomarkersDoxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2.TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation.Alternative lengthening of telomeres in mammalian cells.Cullins and cancer.Study on the expression and mutation of human telomeric repeat binding factor (hTRF1) in 10 malignant hematopoietic cell lines.Telomeres, telomerase, and apoptosis.Reduced expression of TRF1 is associated with tumor progression and poor prognosis in oral squamous cell carcinoma.Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patientsTelomere repeat binding factors TRF1, TRF2, and hRAP1 modulate replication of Epstein-Barr virus OriP9-bromonoscapine-induced mitotic arrest of cigarette smoke condensate-transformed breast epithelial cells.Mitotic perturbations induced by Nek2 overexpression require interaction with TRF1 in breast cancer cells.Nucleolar modulation of TRF1: a dynamic way to regulate telomere and cell cycle by nucleostemin and GNL3L.Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease.DNA damage transiently increases TRF2 mRNA expression and telomerase activity.Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance.Perturbation of NgTRF1 expression induces apoptosis-like cell death in tobacco BY-2 cells and implicates NgTRF1 in the control of telomere length and stability.A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells.Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module.Plk1 phosphorylation of TRF1 is essential for its binding to telomeres.Telomere shortening is correlated with the DNA damage response and telomeric protein down-regulation in colorectal preneoplastic lesions.
P2860
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P2860
Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors
description
2001 nî lūn-bûn
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2001 թուականի Մարտին հրատարակուած գիտական յօդուած
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2001 թվականի մարտին հրատարակված գիտական հոդված
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2001年の論文
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年學術文章
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name
Telomeric protein Pin2/TRF1 in ...... gulated in human breast tumors
@ast
Telomeric protein Pin2/TRF1 in ...... gulated in human breast tumors
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Telomeric protein Pin2/TRF1 in ...... gulated in human breast tumors
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Telomeric protein Pin2/TRF1 in ...... gulated in human breast tumors
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Telomeric protein Pin2/TRF1 in ...... gulated in human breast tumors
@ast
Telomeric protein Pin2/TRF1 in ...... gulated in human breast tumors
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Telomeric protein Pin2/TRF1 in ...... gulated in human breast tumors
@en-gb
Telomeric protein Pin2/TRF1 in ...... gulated in human breast tumors
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prefLabel
Telomeric protein Pin2/TRF1 in ...... gulated in human breast tumors
@ast
Telomeric protein Pin2/TRF1 in ...... gulated in human breast tumors
@en
Telomeric protein Pin2/TRF1 in ...... gulated in human breast tumors
@en-gb
Telomeric protein Pin2/TRF1 in ...... gulated in human breast tumors
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P2093
P2860
P356
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Telomeric protein Pin2/TRF1 in ...... gulated in human breast tumors
@en
P2093
P2860
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P356
10.1038/SJ.ONC.1204229
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P577
2001-03-22T00:00:00Z
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P6179
1048524271