Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity
about
Unwinding and rewinding: double faces of helicase?Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteinsArginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determinationHuman RECQL5 participates in the removal of endogenous DNA damagePhysical and functional interaction of the Werner syndrome protein with poly-ADP ribosyl transferaseWRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication forkRECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombinationStimulation of flap endonuclease-1 by the Bloom's syndrome proteinTelomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicasesPhysical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicasesWerner syndrome protein interacts functionally with translesion DNA polymerasesAsymmetry of DNA replication fork progression in Werner's syndromeThe human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distributionThe spectrum of WRN mutations in Werner syndrome patientsPhysical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factorsKu heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminusAnalysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein ARoles of Werner syndrome protein in protection of genome integrityModel of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromesHuman premature aging, DNA repair and RecQ helicasesGenetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in miceIn vivo and in vitro studies of Mgs1 suggest a link between genome instability and Okazaki fragment processing.The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNAThe interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNACrystal structure of bacteriophage T4 5' nuclease in complex with a branched DNA reveals how flap endonuclease-1 family nucleases bind their substratesThe MPH1 gene of Saccharomyces cerevisiae functions in Okazaki fragment processing.Processing and joining of DNA ends coordinated by interactions among Dnl4/Lif1, Pol4, and FEN-1.The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome proteinPhosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulationRegulation of the Werner helicase through a direct interaction with a subunit of protein kinase ARole of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cellsHuman exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repairCharacterization of the Caenorhabditis elegans HIM-6/BLM helicase: unwinding recombination intermediatesWuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1RecQ helicases: caretakers of the genomeThe protein components and mechanism of eukaryotic Okazaki fragment maturation.RecQ helicases: guardian angels of the DNA replication fork.Acetylation regulates WRN catalytic activities and affects base excision DNA repair.Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA
P2860
Q21296726-E45A7D93-BD30-4CBF-89E4-AA1AA220DDB2Q24292733-5DCB07A0-0AD7-4BE7-B533-9CA5D1212095Q24296440-DD307496-0183-4D5B-9F22-565E1D1B64D7Q24298591-96E684D6-B078-46F3-A99E-65E4CC73489AQ24299153-653DA213-1543-4B1C-A2AE-352491FD5483Q24301121-DC6073D7-976B-408B-9F24-B9714EF3387EQ24301788-C94D978C-F5A5-4D3E-95E6-FF9A8CDC1DF5Q24302463-61BE404D-ADF1-42BE-98B6-C4108A0E04EBQ24304488-AFB65A36-5A5F-49ED-909F-B7B005A03129Q24305559-A7383750-DD4A-4CFD-B09E-6C9186A239CCQ24309639-A26631B5-77E3-4C8B-8DEC-1628E4F196CFQ24311409-492194C5-E84C-4C69-BFFE-8C6F5903AA99Q24316909-923645F4-125D-488A-8DC5-3E7A87C06DFAQ24318820-DC687D08-997F-4B1A-8F86-E382628E2F03Q24324195-BCB64F86-E722-49F1-B3D8-79744BD1AED7Q24338232-530456B2-E1BD-4196-9941-535C0B2B1427Q24538401-87545025-4FFD-4051-938C-392325CFDF82Q24563590-0143C822-87E2-47A8-9565-D4E941480630Q24643050-3C4B1402-E327-4A27-BECE-C1BF60A4CCD8Q24644033-EF2E7B41-721B-49BD-9812-49BEB38CB894Q24680996-651AD08D-7B4F-48D3-B520-72D6CCFB4D64Q24684308-864D1401-70E9-4EBA-BE32-062C58FA3D40Q24812483-62E1B379-BEA2-4833-B5A5-0CE667BA0C6BQ24812850-7749181F-41C6-48F7-A722-FF505B0A8B8DQ24814897-38E74CF9-7A41-42CA-AF9A-EDF0AE6D0363Q27647139-ABAE1AE1-048B-4802-9D08-19926BE32C3EQ27932411-3D30EEC9-4CE5-4D4B-A417-3B9198786D3EQ27939628-C6CC44E6-B03F-481C-9236-DEB555A7A71BQ28155868-C6C0F029-2DC3-4233-BB02-4C4603DEC469Q28186377-24155D15-0558-468B-9A50-B52B0BAB1457Q28204839-D8591B13-F5D2-4E39-AFEF-C78E5BEF50C0Q28271011-BB1299D9-BDCB-4B09-B780-C83026E66307Q28299185-6E236F52-E64B-40F2-B39A-C89972B3D119Q28540907-BD89DAA2-495F-4115-B571-2EC7338CB933Q28552317-642B5E4A-F3DF-48FB-ADDB-7C3AC9773D72Q29618390-E69C6A3C-7D7F-46F9-A240-964AB02DC7F1Q31034204-123789EE-4E45-4826-8A04-C260C9A8C5C0Q33314341-3EFFF81B-6F66-468D-B4F2-6BEC8FA9E24AQ33327349-27325CF3-754E-4198-9A1F-B0ED63F1CD8BQ33529100-9E0390EE-5C44-471A-8E71-B12EF6229738
P2860
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Werner syndrome protein intera ...... imulates its cleavage activity
@ast
Werner syndrome protein intera ...... imulates its cleavage activity
@en
Werner syndrome protein intera ...... imulates its cleavage activity
@en-gb
Werner syndrome protein intera ...... imulates its cleavage activity
@nl
type
label
Werner syndrome protein intera ...... imulates its cleavage activity
@ast
Werner syndrome protein intera ...... imulates its cleavage activity
@en
Werner syndrome protein intera ...... imulates its cleavage activity
@en-gb
Werner syndrome protein intera ...... imulates its cleavage activity
@nl
prefLabel
Werner syndrome protein intera ...... imulates its cleavage activity
@ast
Werner syndrome protein intera ...... imulates its cleavage activity
@en
Werner syndrome protein intera ...... imulates its cleavage activity
@en-gb
Werner syndrome protein intera ...... imulates its cleavage activity
@nl
P2093
P2860
P356
P1433
P1476
Werner syndrome protein intera ...... imulates its cleavage activity
@en
P2093
C von Kobbe
G L Dianov
J A Sommers
J Piotrowski
P Karmakar
P2860
P304
P356
10.1093/EMBOJ/20.20.5791
P407
P577
2001-10-01T00:00:00Z