Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2 - Test2 - elhamkhani - TriplyDB

Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2

Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2

http://www.wikidata.org/entity/Q24292684

about

Human single-stranded DNA binding proteins are essential for maintaining genomic stability Purified human BRCA2 stimulates RAD51-mediated recombination A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising Inflammation-induced cell proliferation potentiates DNA damage-induced mutations in vivo Rad52 inactivation is synthetically lethal with BRCA2 deficiency A dynamic model for replication protein A (RPA) function in DNA processing pathways Protein interactions in human genetic diseases.Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A Human replication protein A. The C-terminal RPA70 and the central RPA32 domains are involved in the interactions with the 3'-end of a primer-template DNA.Uncovering packaging features of co-regulated modules based on human protein interaction and transcriptional regulatory networks XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair.Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52.Replication protein A: directing traffic at the intersection of replication and repair.Rosa26-GFP direct repeat (RaDR-GFP) mice reveal tissue- and age-dependence of homologous recombination in mammals in vivo.EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases.Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods.RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response.Accurate prediction of the binding free energy and analysis of the mechanism of the interaction of replication protein A (RPA) with ssDNA.Theoretical prediction of the binding free energy for mutants of replication protein A.Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer Tumor-associated antigen arrays for the serological diagnosis of cancer.BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families.Fanconi anemia proteins, DNA interstrand crosslink repair pathways, and cancer therapy.Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2 Choreography of recombination proteins during the DNA damage response.A network medicine approach to human disease.Functional assays for analysis of variants of uncertain significance in BRCA2.From protein interaction networks to novel therapeutic strategies.Targeting homologous recombination-mediated DNA repair in cancer.Homologous recombination as a replication fork escort: fork-protection and recovery.Elevated Expression of RPA3 Is Involved in Gastric Cancer Tumorigenesis and Associated with Poor Patient Survival.Replication Protein A 3 Is Associated with Hepatocellular Carcinoma Tumorigenesis and Poor Patient Survival.Full in-frame exon 3 skipping of BRCA2 confers high risk of breast and/or ovarian cancer.

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P2860

Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2

http://www.wikidata.org/entity/Q24292684

description

2003 nî lūn-bûn

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2003 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2003 թվականի հունվարին հրատարակված գիտական հոդված

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2003年の論文

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Interaction between BRCA2 and ...... predisposing mutation in BRCA2

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Interaction between BRCA2 and ...... predisposing mutation in BRCA2

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Interaction between BRCA2 and ...... predisposing mutation in BRCA2

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Interaction between BRCA2 and ...... predisposing mutation in BRCA2

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Interaction between BRCA2 and ...... predisposing mutation in BRCA2

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Interaction between BRCA2 and ...... predisposing mutation in BRCA2

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Interaction between BRCA2 and ...... predisposing mutation in BRCA2

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Interaction between BRCA2 and ...... predisposing mutation in BRCA2

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Interaction between BRCA2 and ...... predisposing mutation in BRCA2

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Interaction between BRCA2 and ...... predisposing mutation in BRCA2

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Interaction between BRCA2 and ...... predisposing mutation in BRCA2

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C James Ingles

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Daniela Ionescu

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Johnson M S Wong

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P2860

BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations.

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

The BRCA2 gene product functionally interacts with p53 and RAD51

CBP/p300 interact with and function as transcriptional coactivators of BRCA1

BRCA1 is a component of the RNA polymerase II holoenzyme

Assessing the requirements for nucleotide excision repair proteins of Saccharomyces cerevisiae in an in vitro system.

RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein

BRCA1 modulates ionizing radiation-induced nuclear focus formation by the replication protein A p34 subunit.

Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins.

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28-33

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scholarly article

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10.1038/SJ.ONC.1206071

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1

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22

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2003-01-09T00:00:00Z

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5398868

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1033515421

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12527904

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