RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2
about
Human single-stranded DNA binding proteins are essential for maintaining genomic stabilityInteraction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammalsExpression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint controlBRCA2 and homologous recombinationInteraction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2FIGNL1-containing protein complex is required for efficient homologous recombination repairPurified human BRCA2 stimulates RAD51-mediated recombinationA mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressorThe role of BRCA2 in replication-coupled DNA interstrand cross-link repair in vitroCDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repairBRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damageAPRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancerInteraction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeatsHighlight: BRCA1 and BRCA2 proteins in breast cancerInteractions between human BRCA2 protein and the meiosis-specific recombinase DMC1RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylationFBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51Insights into DNA recombination from the structure of a RAD51-BRCA2 complexIdentification of a novel human Rad51 variant that promotes DNA strand exchangeThe BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repairDeficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joiningDomain mapping of the Rad51 paralog protein complexesTrypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombinationThe BRCA2 gene product functionally interacts with p53 and RAD51Caretaker Brca1: keeping the genome in the straight and narrow.Distinct functions of BRCA1 and BRCA2 in double-strand break repairThe Icelandic founder mutation BRCA2 999del5: analysis of expressionStrong evidence that the common variant S384F in BRCA2 has no pathogenic relevance in hereditary breast cancer.High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy.Assembly of RecA-like recombinases: distinct roles for mediator proteins in mitosis and meiosisRoles of C-Terminal Region of Yeast and Human Rad52 in Rad51-Nucleoprotein Filament Formation and ssDNA AnnealingHomologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsMolding BRCA2 function through its interacting partnersDSS1 is required for the stability of BRCA2M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complexPhosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progressionThe Fanconi anaemia/BRCA pathwayAnalysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signalsInhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2Unraveling the mechanism of BRCA2 in homologous recombination
P2860
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P2860
RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
RAD51 interacts with the evolu ...... ncer susceptibility gene brca2
@ast
RAD51 interacts with the evolu ...... ncer susceptibility gene brca2
@en
RAD51 interacts with the evolu ...... ncer susceptibility gene brca2
@nl
type
label
RAD51 interacts with the evolu ...... ncer susceptibility gene brca2
@ast
RAD51 interacts with the evolu ...... ncer susceptibility gene brca2
@en
RAD51 interacts with the evolu ...... ncer susceptibility gene brca2
@nl
prefLabel
RAD51 interacts with the evolu ...... ncer susceptibility gene brca2
@ast
RAD51 interacts with the evolu ...... ncer susceptibility gene brca2
@en
RAD51 interacts with the evolu ...... ncer susceptibility gene brca2
@nl
P2093
P2860
P3181
P356
P1476
RAD51 interacts with the evolu ...... ncer susceptibility gene brca2
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.272.51.31941
P407
P577
1997-12-19T00:00:00Z