SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1
about
The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's diseaseSORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processesGGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β productionLysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutationApolipoprotein E receptors in the nervous systemRole of the Retromer Complex in Neurodegenerative DiseasesRisk factor SORL1: from genetic association to functional validation in Alzheimer's diseaseTrafficking and proteolytic processing of APPInteraction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinctionLoss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's diseaseSortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesisAmyloid precursor protein trafficking, processing, and functionIn situ structural characterization of a recombinant protein in native Escherichia coli membranes with solid-state magic-angle-spinning NMR.Multi-compartmental modeling of SORLA's influence on amyloidogenic processing in Alzheimer's diseaseGenetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathologyAlzheimer's disease risk genes and mechanisms of disease pathogenesisMore than cholesterol transporters: lipoprotein receptors in CNS function and neurodegenerationA membrane proximal helix in the cytosolic domain of the human APP interacting protein LR11/SorLA deforms liposomes.The role of apolipoprotein E in Alzheimer's disease.Bacterial expression, purification, and model membrane reconstitution of the transmembrane and cytoplasmic domains of the human APP binding protein LR11/SorLA for NMR studies.BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF.At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis.The Alzheimer's associated 5' region of the SORL1 gene cis regulates SORL1 transcripts expression.LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor.The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability.Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor.Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688Upcoming candidate cerebrospinal fluid biomarkers of Alzheimer's diseaseLDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.The role of intracellular trafficking and the VPS10d receptors in Alzheimer's disease.Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes.Drosophila GGA model: an ultimate gateway to GGA analysis.Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide
P2860
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P2860
SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
SorLA/LR11 regulates processin ...... n with adaptors GGA and PACS-1
@ast
SorLA/LR11 regulates processin ...... n with adaptors GGA and PACS-1
@en
SorLA/LR11 regulates processin ...... n with adaptors GGA and PACS-1
@en-gb
SorLA/LR11 regulates processin ...... n with adaptors GGA and PACS-1
@nl
type
label
SorLA/LR11 regulates processin ...... n with adaptors GGA and PACS-1
@ast
SorLA/LR11 regulates processin ...... n with adaptors GGA and PACS-1
@en
SorLA/LR11 regulates processin ...... n with adaptors GGA and PACS-1
@en-gb
SorLA/LR11 regulates processin ...... n with adaptors GGA and PACS-1
@nl
prefLabel
SorLA/LR11 regulates processin ...... n with adaptors GGA and PACS-1
@ast
SorLA/LR11 regulates processin ...... n with adaptors GGA and PACS-1
@en
SorLA/LR11 regulates processin ...... n with adaptors GGA and PACS-1
@en-gb
SorLA/LR11 regulates processin ...... n with adaptors GGA and PACS-1
@nl
P2093
P2860
P921
P3181
P356
P1476
SorLA/LR11 regulates processin ...... n with adaptors GGA and PACS-1
@en
P2093
Anje Sporbert
Armin Rehm
Michael Rohe
Tatjana Reimer
Vanessa Schmidt
P2860
P304
32956-32964
P3181
P356
10.1074/JBC.M705073200
P407
P577
2007-09-12T00:00:00Z