The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
about
Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase IIP-TEFb goes viralTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsMutual relationships between transcription and pre-mRNA processing in the synthesis of mRNAGene-specific requirement of RNA polymerase II CTD phosphorylationHeterochromatin remodeling by CDK12 contributes to learning in Drosophila.The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor bThe structure and substrate specificity of human Cdk12/Cyclin KGenome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized MedicineA positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeastCyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cellsThreonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongationFUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2.Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cellsCharacterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast.Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies.Antisense-mediated FLC transcriptional repression requires the P-TEFb transcription elongation factor.CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.Cyclin-dependent kinasesRNA polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation: A tail of two kinases.In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation.The RNA polymerase II CTD coordinates transcription and RNA processing.CDK9 and H2B monoubiquitination: a well-choreographed dance.RNA polymerase II CTD modifications: how many tales from a single tail.Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA RepairThe Molecular Taxonomy of Primary Prostate Cancer.Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts.RNA polymerase II transcription elongation control.PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth.Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processingExpression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.A distinct expression pattern of cyclin K in mammalian testes suggests a functional role in spermatogenesis.Targeting cell cycle regulators in hematologic malignancies.Promoter nucleosome dynamics regulated by signalling through the CTD codeCDK13, a Kinase Involved in Pre-mRNA Splicing, Is a Component of the Perinucleolar Compartment.Proteogenomics connects somatic mutations to signalling in breast cancer.Functional genomics identifies therapeutic targets for MYC-driven cancer.Genomic profiling of multiple sequentially acquired tumor metastatic sites from an "exceptional responder" lung adenocarcinoma patient reveals extensive genomic heterogeneity and novel somatic variants driving treatment response
P2860
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P2860
The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The Cyclin K/Cdk12 complex mai ...... n of DNA damage response genes
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The Cyclin K/Cdk12 complex mai ...... n of DNA damage response genes
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The Cyclin K/Cdk12 complex mai ...... n of DNA damage response genes
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The Cyclin K/Cdk12 complex mai ...... n of DNA damage response genes
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The Cyclin K/Cdk12 complex mai ...... n of DNA damage response genes
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The Cyclin K/Cdk12 complex mai ...... n of DNA damage response genes
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The Cyclin K/Cdk12 complex mai ...... n of DNA damage response genes
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The Cyclin K/Cdk12 complex mai ...... n of DNA damage response genes
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The Cyclin K/Cdk12 complex mai ...... n of DNA damage response genes
@ast
The Cyclin K/Cdk12 complex mai ...... n of DNA damage response genes
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The Cyclin K/Cdk12 complex mai ...... n of DNA damage response genes
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The Cyclin K/Cdk12 complex mai ...... n of DNA damage response genes
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P2093
P2860
P921
P3181
P356
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The Cyclin K/Cdk12 complex mai ...... n of DNA damage response genes
@en
P2093
B Matija Peterlin
Eric Johansen
Jiri Kohoutek
Koen Bartholomeeusen
Peter Cimermancic
Petra Hulinkova
Zeping Luo
P2860
P304
P3181
P356
10.1101/GAD.16962311
P407
P577
2011-10-15T00:00:00Z