Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II
about
The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancerTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsHeterochromatin remodeling by CDK12 contributes to learning in Drosophila.The structure and substrate specificity of human Cdk12/Cyclin KCDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts.Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processingExpression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapyOvarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.A distinct expression pattern of cyclin K in mammalian testes suggests a functional role in spermatogenesis.Targeting cell cycle regulators in hematologic malignancies.SIRT2 directs the replication stress response through CDK9 deacetylation.Cdk12 is essential for embryonic development and the maintenance of genomic stability.Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitorsIntegrated proteomic analysis of post-translational modifications by serial enrichment.Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors.Deregulations in the cyclin-dependent kinase-9-related pathway in cancer: implications for drug discovery and development.The pol II CTD: new twists in the tail.CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.TP53 Regulates Transcription of DNA Repair GenesThe emerging roles of CDK12 in tumorigenesis.BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors.CDK12 phosphorylates RNA Pol II CTD at DNA repair genesThe cyclin-dependent kinase G group defines a thermo-sensitive alternative splicing circuit modulating the expression of Arabidopsis ATU2AF65A.Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation.The Ethnic-Specific Spectrum of Germline Nucleotide Variants in DNA Damage Response and Repair Genes in Hereditary Breast and Ovarian Cancer Patients of Tatar DescentStructural insights into the functional diversity of the CDK-cyclin family
P2860
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P2860
Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Interaction of cyclin-dependen ...... al domain of RNA polymerase II
@ast
Interaction of cyclin-dependen ...... al domain of RNA polymerase II
@en
Interaction of cyclin-dependen ...... al domain of RNA polymerase II
@en-gb
Interaction of cyclin-dependen ...... al domain of RNA polymerase II
@nl
type
label
Interaction of cyclin-dependen ...... al domain of RNA polymerase II
@ast
Interaction of cyclin-dependen ...... al domain of RNA polymerase II
@en
Interaction of cyclin-dependen ...... al domain of RNA polymerase II
@en-gb
Interaction of cyclin-dependen ...... al domain of RNA polymerase II
@nl
prefLabel
Interaction of cyclin-dependen ...... al domain of RNA polymerase II
@ast
Interaction of cyclin-dependen ...... al domain of RNA polymerase II
@en
Interaction of cyclin-dependen ...... al domain of RNA polymerase II
@en-gb
Interaction of cyclin-dependen ...... al domain of RNA polymerase II
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Interaction of cyclin-dependen ...... al domain of RNA polymerase II
@en
P2093
Annie Moradian
Marco A Marra
Michael A Kuzyk
S-W Grace Cheng
Sarah E Vollett
Taka-Aki Ichu
Vicky C-D Chang
P2860
P304
P3181
P356
10.1128/MCB.06267-11
P407
P577
2012-11-01T00:00:00Z