about
sameAs
P129
P688
Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized stateBehavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient miceSubstitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signalingA presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradationPurification and characterization of the human gamma-secretase complexPresenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutationsFamilial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complexDifferent effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cellsThe presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-cateninThe novel presenilin-1-associated protein is a proapoptotic mitochondrial proteinAlzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregationAlzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formationEndoproteolysis of presenilin 1 and accumulation of processed derivatives in vivoCloning of a gene bearing missense mutations in early-onset familial Alzheimer's diseasePresenilin 1 associates with glycogen synthase kinase-3beta and its substrate tauTwo homologous genes causing early-onset familial Alzheimer's diseaseMetabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion proteinRole of presenilin 1 in structural plasticity of cortical dendritic spines in vivoProton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavageLigand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptorAn atomic structure of human γ-secretasePresenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.Memory impairment in transgenic Alzheimer mice requires cellular prion protein.Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearanceLigand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway.The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress.A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations.G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice.Dual pathways mediate β-amyloid stimulated glutathione release from astrocytes.
P921
Q22010752-599F49D6-3231-4134-98A6-06604DDC0E85Q22254058-96992697-8EF3-44A1-9932-137EF33A2206Q22254072-A10D920D-0A79-42D1-8ED4-EF54A5747706Q24290586-D6D21632-0964-46C7-A60E-26114AC3863DQ24294366-3FD097D8-7093-412B-9E89-231E8C4728BCQ24296704-8BB194C6-9BC8-46C3-83AA-806B60FC48C0Q24300026-FE2B6A68-BD51-427B-9BEE-0F4AC94F48C3Q24301868-CD57CDFB-052E-40EA-B106-399F5AF51419Q24302464-652B753D-7823-499D-AFBE-07F7A41FD07EQ24303928-6380913A-7FE0-4035-A298-AD5E1A34B6C1Q24306519-F5DE2AD5-ED8D-49D7-848C-8CBDAEE5AA31Q24308766-47B8D0B2-BC35-4E30-BB6B-4A8AA44D1FCDQ24310855-BDD8E34D-6C5E-499A-BBA5-D8953763EF3FQ24312000-FCB29A2C-CD68-4689-85DC-DC5BCA74EAF3Q24314297-57E82809-D8E2-4112-9930-4586A746E086Q24315707-1423912B-9BAD-4689-B0C6-8CA89F77E57FQ24316501-C154C096-87CF-4539-91EA-1DB0A1B69E67Q24320124-3A673D06-62A1-4110-850A-D122A0EBA20BQ24321451-BA8EDD98-AA39-4F4D-89F7-2B5209AED72AQ24322990-B49490C3-773E-4274-AECA-E3B859670D40Q24338802-7BC34629-B018-4D0B-8544-3C83E26BE576Q27014952-D57BC76C-5390-4571-BD2A-D4F26556C8ACQ28115734-44885A4D-7F9D-4645-8710-DBC5B3B1D66BQ28116260-2F763E07-FB5C-4541-A0D1-E0F1CBDDC78FQ28910198-510D6095-8907-40DD-AAF7-B639FE8D1FF8Q29976920-6E7F6580-43BC-4786-829F-9254219A1E80Q30032301-366FD529-091B-4679-9B2B-E14C268173F4Q30274556-F7921AE1-DD15-44F5-85BA-4CA96765A769Q31814817-65022C5E-BDF0-4AAA-8E93-106DD2CA2328Q33292445-4B8AF348-4D10-49C0-982F-70EB0947EF96Q34464152-6AE4EC06-795F-46EA-8659-1062487E2AF1Q37368308-88DE4729-CFCC-4BBC-8530-98C68588B08EQ37483116-B0B3A2E2-05FE-4454-9732-0D6E2E07E204Q40581491-16B07608-D022-4D36-B3F1-8F3540E172D5Q41663079-7A3A4C1F-8FFF-45A4-8718-80C42FFF6A38Q47614851-6ADC57E3-C0CD-4559-8E82-EF9E0633100AQ53478464-0E267BC8-26A1-4871-B614-8FCFC3361513
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Presenilin 1
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
PSEN1
@es
Presenilin 1
@en
Préséniline 1
@fr
Пресенилин-1
@ru
type
label
PSEN1
@es
Presenilin 1
@en
Préséniline 1
@fr
Пресенилин-1
@ru
altLabel
PSEN1
@en
PSEN1
@ru
Protein S182
@en
presenilin-1 isoform I-467
@en
presenilin-1
@en
Пресенилин 1
@ru
prefLabel
PSEN1
@es
Presenilin 1
@en
Préséniline 1
@fr
Пресенилин-1
@ru
P637
P638
P680
P681
P682
P705
P352
P129
P31
P352
P637
XP_005267921
XP_005267923
XP_011535274
XP_011535275
XP_011535276
P638
P680
P681
P682
P702
P703
P705
ENSP00000326366
ENSP00000350342
ENSP00000377712
ENSP00000377719
ENSP00000385948
ENSP00000450551
ENSP00000450652
ENSP00000450845
ENSP00000451347
ENSP00000451429
P7260
1.A.54.1.1