BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly - Test2 - elhamkhani - TriplyDB

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly

http://www.wikidata.org/entity/Q24295491

about

A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened Chaperonin-containing TCP-1 complex directly binds to the cytoplasmic domain of the LOX-1 receptor Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes Characterization of CCDC28B reveals its role in ciliogenesis and provides insight to understand its modifier effect on Bardet-Biedl syndrome Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable bardet-biedl syndrome protein complex, the BBSome BBS mutations modify phenotypic expression of CEP290-related ciliopathies The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome The blind leading the obese: the molecular pathophysiology of a human obesity syndrome Novel transglutaminase-like peptidase and C2 domains elucidate the structure, biogenesis and evolution of the ciliary compartment The role of primary cilia in the development and disease of the retina Scrutinizing ciliopathies by unraveling ciliary interaction networks CEP290 alleles in mice disrupt tissue-specific cilia biogenesis and recapitulate features of syndromic ciliopathies An engineering approach to extending lifespan in C. elegans Ectopic expression of human BBS4 can rescue Bardet-Biedl syndrome phenotypes in Bbs4 null mice ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting Trafficking in and to the primary cilium.CP110 and its network of partners coordinately regulate cilia assembly.The roles of evolutionarily conserved functional modules in cilia-related trafficking.Nephronophthisis and related syndromes Biology and therapy of inherited retinal degenerative disease: insights from mouse models A novel H395R mutation in MKKS/BBS6 causes retinitis pigmentosa and polydactyly without other findings of Bardet-Biedl or McKusick-Kaufman syndrome Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery Bardet-Biedl syndrome proteins control the cilia length through regulation of actin polymerization Knockdown of Bardet-Biedl syndrome gene BBS9/PTHB1 leads to cilia defects Pharmacological modulation of the retinal unfolded protein response in Bardet-Biedl syndrome reduces apoptosis and preserves light detection ability Ciliopathy is differentially distributed in the brain of a Bardet-Biedl syndrome mouse model An organelle-specific protein landscape identifies novel diseases and molecular mechanisms Contrasting vascular effects caused by loss of Bardet-Biedl syndrome genes.Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms.Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia.CCTalpha and CCTdelta chaperonin subunits are essential and required for cilia assembly and maintenance in Tetrahymena.From the cytoplasm into the cilium: bon voyage.Essential role of the chaperonin CCT in rod outer segment biogenesis Systems biology and proteomic analysis of cerebral cavernous malformation Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia Ciliopathies: the trafficking connection.The eukaryotic flagellum makes the day: novel and unforeseen roles uncovered after post-genomics and proteomics data.

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P2860

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly

http://www.wikidata.org/entity/Q24295491

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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PNAS.0910268107

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

BBS6, BBS10, and BBS12 form a ...... s and mediate BBSome assembly.

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P2093

Diane C Slusarski

http://www.w3.org/2001/XMLSchema#string

John S Beck

http://www.w3.org/2001/XMLSchema#string

Lisa M Baye

http://www.w3.org/2001/XMLSchema#string

Nathan P Schulz

http://www.w3.org/2001/XMLSchema#string

Qihong Zhang

http://www.w3.org/2001/XMLSchema#string

Seongjin Seo

http://www.w3.org/2001/XMLSchema#string

Val C Sheffield

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P2860

The Ciliopathies: An Emerging Class of Human Genetic Disorders

Functional organization of the yeast proteome by systematic analysis of protein complexes

Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome

Bardet-Biedl syndrome genes are important in retrograde intracellular trafficking and Kupffer's vesicle cilia function

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

Loss of Bardet-Biedl syndrome proteins alters the morphology and function of motile cilia in airway epithelia

Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3)

Comparative genomics and gene expression analysis identifies BBS9, a new Bardet-Biedl syndrome gene

Clinical and genetic epidemiology of Bardet-Biedl syndrome in Newfoundland: a 22-year prospective, population-based, cohort study

P304

1488-93

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scholarly article

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1656642

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10.1073/PNAS.0910268107

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4

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107

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41040305

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20080638

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P921

Chaperonin containing TCP1 subunit 2

Bardet-Biedl syndrome 9

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Bardet-Biedl syndrome 10

Bardet-Biedl syndrome 7

Bardet-Biedl syndrome 1

Bardet-Biedl syndrome 4

Tetratricopeptide repeat domain 8

P932

2824390

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