An interconnected hierarchical model of cell death regulation by the BCL-2 family
about
Mitochondrial apoptosis and BH3 mimeticsThe Stability and Expression Level of Bok Are Governed by Binding to Inositol 1,4,5-Trisphosphate ReceptorsAssembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic poreOxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and PumaCycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only ProteinsDeubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms.Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane.Physiological restraint of Bak by Bcl-xL is essential for cell survival.Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation.Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasisCarfilzomib Triggers Cell Death in Chronic Lymphocytic Leukemia by Inducing Proapoptotic and Endoplasmic Reticulum Stress Responses.The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane.The VDAC2-BAK axis regulates peroxisomal membrane permeability.Mitochondria-Judges and Executioners of Cell Death Sentences.Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis.MicroRNA-25 Negatively Regulates Cerebral Ischemia/Reperfusion Injury-Induced Cell Apoptosis Through Fas/FasL Pathway.Physiological and Pharmacological Control of BAK, BAX, and Beyond.Bax and Bak Pores: Are We Closing the Circle?Apoptotic foci at mitochondria: in and around Bax pores.An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation.Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy.Spontaneous loss of B lineage transcription factors leads to pre-B leukemia in Ebf1+/-Bcl-xLTg miceMitochondrial outer membrane permeabilization: a focus on the role of mitochondrial membrane structural organization.Human colorectal cancer cells induce vascular smooth muscle cell apoptosis in an exocrine mannerDeletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in miceSelf-regulation of BAX-induced cell death.Pro-death activity of a BH3 domain in an aquaporin from the protozoan parasite Leishmania.Autophagy may play an important role in varicocele.The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax.BAK regulates catalase release from peroxisomes.Why do BCL-2 inhibitors work and where should we use them in the clinic?Transcription Factor C/EBP Homologous Protein in Health and Diseases.ΔNp63 Inhibits Oxidative Stress-Induced Cell Death, Including Ferroptosis, and Cooperates with the BCL-2 Family to Promote Clonogenic Survival.Measurement of BH3-only protein tolerance.Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells.The C-terminal Domains of Apoptotic BH3-only Proteins Mediate Their Insertion into Distinct Biological Membranes.Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins.MCL-1 keeps a charming home for thymocytes.
P2860
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P2860
An interconnected hierarchical model of cell death regulation by the BCL-2 family
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
An interconnected hierarchical model of cell death regulation by the BCL-2 family
@ast
An interconnected hierarchical model of cell death regulation by the BCL-2 family
@en
type
label
An interconnected hierarchical model of cell death regulation by the BCL-2 family
@ast
An interconnected hierarchical model of cell death regulation by the BCL-2 family
@en
prefLabel
An interconnected hierarchical model of cell death regulation by the BCL-2 family
@ast
An interconnected hierarchical model of cell death regulation by the BCL-2 family
@en
P2093
P2860
P356
P1433
P1476
An interconnected hierarchical model of cell death regulation by the BCL-2 family
@en
P2093
Akane Inoue-Yamauchi
Chung-Ping Liao
Decheng Ren
Denis E Reyna
Emily H Cheng
Ho-Chou Tu
Hui-Chen Chen
Hyungjin Kim
James J Hsieh
Masayuki Kanai
P2860
P2888
P304
P356
10.1038/NCB3236
P577
2015-09-07T00:00:00Z