Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair
about
Analysis of miRNA and mRNA expression profiles highlights alterations in ionizing radiation response of human lymphocytes under modeled microgravityOncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathwayDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsWhat goes on must come off: phosphatases gate-crash the DNA damage responseWip1 phosphatase: between p53 and MAPK kinases pathwaysWee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapyThe oncogenic phosphatase WIP1 negatively regulates nucleotide excision repairWIP1 phosphatase as pharmacological target in cancer therapy.Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage responsePhosphatases in the cellular response to DNA damage.Overexpression of wip1 is associated with biologic behavior in human clear cell renal cell carcinoma.UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cellsActivation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damageProtein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaksWIP1 phosphatase as a potential therapeutic target in neuroblastomaTPX2 impacts acetylation of histone H4 at lysine 16: implications for DNA damage response.Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.Chromatin structure following UV-induced DNA damage-repair or death?Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damageHDM2 promotes WIP1-mediated medulloblastoma growth.TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response.Regulation of the Wip1 phosphatase and its effects on the stress response.Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres.DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase.Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway.Binding of a third metal ion by the human phosphatases PP2Cα and Wip1 is required for phosphatase activityROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.Dephosphorylation of γ-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control.Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication.Imatinib induces H2AX phosphorylation and apoptosis in chronic myelogenous leukemia cells in vitro via caspase-3/Mst1 pathway.Serine/threonine phosphatases in the DNA damage response and cancer.Checkpoint control and cancer.Ionizing radiation-induced responses in human cells with differing TP53 status.Wip1 phosphatase in breast cancer.Controlling the response to DNA damage by the APC/C-Cdh1.LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro.p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity.Spontaneous γH2AX Foci in Human Solid Tumor-Derived Cell Lines in Relation to p21WAF1 and WIP1 Expression.Involvement of ROS-p38-H2AX axis in novel curcumin analogues-induced apoptosis in breast cancer cells.Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis.
P2860
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P2860
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Wild-type p53-induced phosphat ...... DNA double strand break repair
@ast
Wild-type p53-induced phosphat ...... DNA double strand break repair
@en
Wild-type p53-induced phosphat ...... DNA double strand break repair
@en-gb
Wild-type p53-induced phosphat ...... DNA double strand break repair
@nl
type
label
Wild-type p53-induced phosphat ...... DNA double strand break repair
@ast
Wild-type p53-induced phosphat ...... DNA double strand break repair
@en
Wild-type p53-induced phosphat ...... DNA double strand break repair
@en-gb
Wild-type p53-induced phosphat ...... DNA double strand break repair
@nl
prefLabel
Wild-type p53-induced phosphat ...... DNA double strand break repair
@ast
Wild-type p53-induced phosphat ...... DNA double strand break repair
@en
Wild-type p53-induced phosphat ...... DNA double strand break repair
@en-gb
Wild-type p53-induced phosphat ...... DNA double strand break repair
@nl
P2093
P2860
P3181
P356
P1476
Wild-type p53-induced phosphat ...... DNA double strand break repair
@en
P2093
Alan S Waldman
Lawrence A Donehower
Sung-Hwan Moon
Xinna Zhang
Xiongbin Lu
Yolanda Darlington
P2860
P304
12935-12947
P3181
P356
10.1074/JBC.M109.071696
P407
P577
2010-01-29T00:00:00Z