PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints - Test2 - elhamkhani - TriplyDB

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

http://www.wikidata.org/entity/Q24527393

about

Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1)Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B What goes on must come off: phosphatases gate-crash the DNA damage response Wip1 phosphatase: between p53 and MAPK kinases pathways Noncoding RNAs in DNA repair and genome integrity Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy DNA damage control: regulation and functions of checkpoint kinase 1 Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase Roles of Chk1 in cell biology and cancer therapy Dysregulated estrogen receptor signaling in the hypothalamic-pituitary-ovarian axis leads to ovarian epithelial tumorigenesis in mice Fourier analysis and systems identification of the p53 feedback loop Distinct phosphatases antagonize the p53 response in different phases of the cell cycle A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair Ataxin-3 promotes genome integrity by stabilizing Chk1.Interplay between Mdm2 and HIPK2 in the DNA damage response.Phosphatases reverse p53-mediated cell cycle checkpoints ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.WIP1 phosphatase as pharmacological target in cancer therapy.Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation.Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.The ups and downs of p53: understanding protein dynamics in single cells The p53 orchestra: Mdm2 and Mdmx set the tone PPM1D silencing by RNA interference inhibits the proliferation of lung cancer cells Phosphatases in the cellular response to DNA damage.Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation.Deficiency of the tumor promoter gene wip1 induces insulin resistance.EDD inhibits ATM-mediated phosphorylation of p53.Dynamics of the transcriptome response of cultured human embryonic stem cells to ionizing radiation exposure.

P2860

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P2860

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

http://www.wikidata.org/entity/Q24527393

description

2005 nî lūn-bûn

@nan

2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2005 թվականի մայիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

@ast

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

@en

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

@en-gb

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

@nl

type

label

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

@ast

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

@en

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

@en-gb

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

@nl

prefLabel

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

@ast

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

@en

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

@en-gb

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

@nl

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P2860

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Genes & Development

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

@en

P2093

Bonnie Nannenga

http://www.w3.org/2001/XMLSchema#string

Lawrence A Donehower

http://www.w3.org/2001/XMLSchema#string

Xiongbin Lu

http://www.w3.org/2001/XMLSchema#string

P2860

A role for ATR in the DNA damage-induced phosphorylation of p53

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways.

Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

The DNA damage response: putting checkpoints in perspective

P304

1162-74

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scholarly article

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3559204

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10.1101/GAD.1291305

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10

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19

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2005-05-15T00:00:00Z

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7868658

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15870257

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1132003

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