A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability
about
The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex componentsSCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myelomaPRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitryPhosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complexThe RNA Splicing Response to DNA DamageSubstrate recognition and function of the R2TP complex in response to cellular stressThe ancient and evolving roles of cohesin in gene expression and DNA repairNutrient regulation of the mTOR complex 1 signaling pathwayStructural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1The DNA Damage Response: Making It Safe to Play with KnivesSaccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response.The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function.ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancersOnline GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis.Identification of novel human damage response proteins targeted through yeast orthology.SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathwayInositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage.PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformationMaking sense of cancer genomic data.RNAi screening: new approaches, understandings, and organisms.Genetic and physical interactions between Tel2 and the Med15 Mediator subunit in Saccharomyces cerevisiae.A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress responseOptimized PCR conditions and increased shRNA fold representation improve reproducibility of pooled shRNA screens.Drosophila Tel2 is expressed as a translational fusion with EpsinR and is a regulator of wingless signalingIdentification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer.Defining genome maintenance pathways using functional genomic approachesA functional screen identifies miRs that induce radioresistance in glioblastomas.Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancersLabel-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression.A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription FactorsModularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteomeA genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation.Mutability and mutational spectrum of chromosome transmission fidelity genesGenetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1.Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognitionMELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cellsA whole genome RNAi screen identifies replication stress response genes.Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.
P2860
Q21144957-EF6D199F-E2C0-492B-8214-4A424C2A2908Q24306820-61BF23FF-5E1E-4139-93E4-517554D2641FQ24312535-A5CC9F23-8281-4727-8B88-8A601401FDB0Q24339507-D7EC024E-76F0-4852-ACB3-A0422546975FQ26777046-85EDD413-84C0-44A2-BEB7-DF3E49A86761Q26824496-19CD29FC-F3CC-4400-BB0C-62F5182CC8C7Q27014855-7B0B4D74-0CBA-4324-B2B5-49A13809D9FBQ27027823-C1F49AE3-C31A-4D1A-AA82-6FA50FACE5ECQ27683635-C0D6C42C-798D-4023-8B9B-F336EC0A9926Q27861055-FA710F45-8DA7-410A-85FD-769C9BDCB672Q27933225-735581A2-D0F1-44B0-8B3C-1C197FA350C8Q27937771-F4161212-709C-41E4-A994-16EAAB27DE1BQ28271111-95D6621C-D16E-445E-AF35-B0490CCF27CBQ30831501-9883EC2F-A9D6-4D26-9A8B-83EF8E1F008EQ31061948-23880F8A-8802-4504-9833-86B843F3D15CQ31171264-167853A4-DF66-46D6-AC80-0CC30A6F4478Q33570316-F21EC9A4-002B-4AE7-BD6F-FCF23C6F82FFQ33715275-302C9BBA-6151-4C7A-90A6-D1BACAA96733Q33743600-B9F97164-DBC2-40EE-835D-FBF5EEA9D620Q33846850-1604B9DD-335F-4943-B5FF-328905B8B163Q34033373-0C11BD4D-5103-430D-BCC6-8DE974C04369Q34146078-2E0966B6-74BD-4D70-9749-2AC9FD935B63Q34313054-738209E6-A5B9-4620-9E33-463B53E8080AQ34369461-F7EADA70-5A22-4B8F-A157-20804707018EQ34431135-77A7543C-D831-42A8-8572-BB204393AD4AQ35000673-6F7D67EC-925D-45CC-9DAE-CFF672F7BD08Q35130588-A1FB8C04-A48E-412D-8F56-3949E41FC647Q35285532-4606D6AD-7C57-4D9A-852D-B7B7F1D67D42Q35577014-CBC00049-ADEE-419F-AEA4-D5497D27C2C1Q35636826-EEC52FBA-AB64-4A6D-A091-46EC4AF36541Q35640249-BBD6D068-02C4-4A72-A06B-79B139452AB4Q35682105-C914A8FE-951A-4011-9F9A-8603D32D1D93Q35791205-71350B1B-385C-429E-9C85-D5E2B1340ED7Q35868661-0DCC3A53-C407-4661-A77E-DB02710591F3Q35954461-F81CF4CC-7CBA-48A5-B05A-7834AF4DD108Q36076885-7EB70E94-8D72-43AF-8DE6-37E019B11B1AQ36115403-64195080-1429-47C2-85ED-0E11C9C83D57Q36275700-15ED2B57-390C-4444-893B-FA5BEB54F186Q36296592-528DB10E-FF56-4FB7-9074-685CA11E56E6Q36532572-D851E4BE-4569-40A3-918C-155FE049EC11
P2860
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A genetic screen identifies th ...... ling and ATM and ATR stability
@ast
A genetic screen identifies th ...... ling and ATM and ATR stability
@en
A genetic screen identifies th ...... ling and ATM and ATR stability
@en-gb
A genetic screen identifies th ...... ling and ATM and ATR stability
@nl
type
label
A genetic screen identifies th ...... ling and ATM and ATR stability
@ast
A genetic screen identifies th ...... ling and ATM and ATR stability
@en
A genetic screen identifies th ...... ling and ATM and ATR stability
@en-gb
A genetic screen identifies th ...... ling and ATM and ATR stability
@nl
prefLabel
A genetic screen identifies th ...... ling and ATM and ATR stability
@ast
A genetic screen identifies th ...... ling and ATM and ATR stability
@en
A genetic screen identifies th ...... ling and ATM and ATR stability
@en-gb
A genetic screen identifies th ...... ling and ATM and ATR stability
@nl
P2860
P921
P3181
P356
P1433
P1476
A genetic screen identifies th ...... ling and ATM and ATR stability
@en
P2093
Cecilia Cotta-Ramusino
Kristen E Hurov
P2860
P304
P3181
P356
10.1101/GAD.1934210
P407
P577
2010-09-01T00:00:00Z