The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components - Test2 - elhamkhani - TriplyDB

The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components

The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components

http://www.wikidata.org/entity/Q21144957

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Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells A new generation of human artificial chromosomes for functional genomics and gene therapy The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2 Yeast: a simple model system to study complex phenomena of aneuploidy Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response.Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae.An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development Reverse PCA, a systematic approach for identifying genes important for the physical interaction between protein pairs A novel multiplexed, image-based approach to detect phenotypes that underlie chromosome instability in human cells Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells Mechanisms of genome instability induced by RNA-processing defects.Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes Genetic and physical interactions between Tel2 and the Med15 Mediator subunit in Saccharomyces cerevisiae.Synthetic lethality of cohesins with PARPs and replication fork mediators.Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1 Karyotypic determinants of chromosome instability in aneuploid budding yeast.Saccharomyces cerevisiae as a model system to study the response to anticancer agents.Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition.Cyclin B2 and p53 control proper timing of centrosome separation Leveraging DNA damage response signaling to identify yeast genes controlling genome stability.R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants Single-Cell Based Quantitative Assay of Chromosome Transmission Fidelity Synergistic Control of Kinetochore Protein Levels by Psh1 and Ubr2.Combined Use of Gene Expression Modeling and siRNA Screening Identifies Genes and Pathways Which Enhance the Activity of Cisplatin When Added at No Effect Levels to Non-Small Cell Lung Cancer Cells In Vitro.Mutability and mutational spectrum of chromosome transmission fidelity genes Fluorescent foci quantitation for high-throughput analysis.Reciprocal uniparental disomy in yeast Genetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1.Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.Haploid yeast cells undergo a reversible phenotypic switch associated with chromosome II copy number Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants.Bioinformatic identification of genes suppressing genome instability Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork.Aneuploidy in health, disease, and aging.Whole Genome Analysis of 132 Clinical Saccharomyces cerevisiae Strains Reveals Extensive Ploidy Variation Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells.

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The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components

http://www.wikidata.org/entity/Q21144957

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2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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JOURNAL.PGEN.1002057

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The complete spectrum of yeast ...... s for ASTRA complex components

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Kyungjae Myung

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Megan Kofoed

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Michelle S Bloom

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Payal Sipahimalani

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Stephanie Smith

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Tejomayee Solanki-Patil

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Zhijian Li

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P2860

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability

CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability

Tel2 regulates the stability of PI3K-related protein kinases

AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly

COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer

A census of human cancer genes

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

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e1002057

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10.1371/JOURNAL.PGEN.1002057

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Peter C. Stirling

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2011-04-01T00:00:00Z

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51107826

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21552543

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3084213

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