Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
about
HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACKRegulation of Ack1 localization and activity by the amino-terminal SAM domainShepherding AKT and androgen receptor by Ack1 tyrosine kinaseMechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segmentChk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signallingRaf family kinases: old dogs have learned new tricksConstitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynaminGADD45gamma: a new vitamin D-regulated gene that is antiproliferative in prostate cancer cellsThe Role of Mir-148a in CancerThe role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancerProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesTargeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunitiesInhibition of Receptor Dimerization as a Novel Negative Feedback Mechanism of EGFR SignalingStructural analysis of the catalytically inactive kinase domain of the human EGF receptor 3Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 ProteinErlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domainAck1: Activation and Regulation by AllosteryCrystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiationStructural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesisIntegrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinomaErbB polymorphisms: insights and implications for response to targeted cancer therapeuticsThe molecular circuitry of brassinosteroid signalingGene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cellsMitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant TransformationGlucocorticoid-induced suppression of β-cell proliferation is mediated by Mig6Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1.A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations.Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.Multiple actions of lysophosphatidic acid on fibroblasts revealed by transcriptional profilingHer4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro systemPhosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling.Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury.Co-conserved features associated with cis regulation of ErbB tyrosine kinases.Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity.Mig-6 controls EGFR trafficking and suppresses gliomagenesisSimultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor.Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation.Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica.
P2860
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P2860
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Inhibition of the EGF receptor ...... vating kinase domain interface
@ast
Inhibition of the EGF receptor ...... vating kinase domain interface
@en
Inhibition of the EGF receptor ...... vating kinase domain interface
@en-gb
Inhibition of the EGF receptor ...... vating kinase domain interface
@nl
type
label
Inhibition of the EGF receptor ...... vating kinase domain interface
@ast
Inhibition of the EGF receptor ...... vating kinase domain interface
@en
Inhibition of the EGF receptor ...... vating kinase domain interface
@en-gb
Inhibition of the EGF receptor ...... vating kinase domain interface
@nl
prefLabel
Inhibition of the EGF receptor ...... vating kinase domain interface
@ast
Inhibition of the EGF receptor ...... vating kinase domain interface
@en
Inhibition of the EGF receptor ...... vating kinase domain interface
@en-gb
Inhibition of the EGF receptor ...... vating kinase domain interface
@nl
P2093
P2860
P3181
P356
P1433
P1476
Inhibition of the EGF receptor ...... vating kinase domain interface
@en
P2093
Kerry A Pickin
Natalia Jura
Philip A Cole
Xuewu Zhang
P2860
P2888
P3181
P356
10.1038/NATURE05998
P407
P50
P577
2007-11-29T00:00:00Z
P5875
P6179
1050194584