The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics
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The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIαThe fifth adaptor protein complexRecruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surfaceThe Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migrationIdentification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recyclingRab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiersCOMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7AEndosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromerA global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transportRME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation.Role of the Retromer Complex in Neurodegenerative DiseasesThe retromer complex - endosomal protein recycling and beyondFunction and regulation of the endosomal fusion and fission machineriesPhosphoinositides in the mammalian endo-lysosomal networkActin polymerization controls the organization of WASH domains at the surface of endosomesThe spectrum of KIAA0196 variants, and characterization of a murine knockout: implications for the mutational mechanism in hereditary spastic paraplegia type SPG8.Rab GTPase regulation of retromer-mediated cargo export during endosome maturation.Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein AggregationThe role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sortingRetromer-mediated endosomal protein sorting: all WASHed up!Recent advances in retromer biologyVPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteinsDendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell primingCCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDLAn ESCRT-spastin interaction promotes fission of recycling tubules from the endosome.Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15.Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagyDefects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegiaEvolutionary variations of VPS29, and their implications for the heteropentameric model of retromerRetromer: a master conductor of endosome sorting.Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndromeRetromer regulates HIV-1 envelope glycoprotein trafficking and incorporation into virions.The giardial VPS35 retromer subunit is necessary for multimeric complex assembly and interaction with the vacuolar protein sorting receptorNuclear FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells.Physiology and pathology of endosome-to-Golgi retrograde sorting.The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.Strumpellin and Spartin, Hereditary Spastic Paraplegia Proteins, are Binding Partners.An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I.Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.
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P2860
The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The cargo-selective retromer c ...... late endosomal tubule dynamics
@ast
The cargo-selective retromer c ...... late endosomal tubule dynamics
@en
The cargo-selective retromer c ...... late endosomal tubule dynamics
@en-gb
The cargo-selective retromer c ...... late endosomal tubule dynamics
@nl
type
label
The cargo-selective retromer c ...... late endosomal tubule dynamics
@ast
The cargo-selective retromer c ...... late endosomal tubule dynamics
@en
The cargo-selective retromer c ...... late endosomal tubule dynamics
@en-gb
The cargo-selective retromer c ...... late endosomal tubule dynamics
@nl
prefLabel
The cargo-selective retromer c ...... late endosomal tubule dynamics
@ast
The cargo-selective retromer c ...... late endosomal tubule dynamics
@en
The cargo-selective retromer c ...... late endosomal tubule dynamics
@en-gb
The cargo-selective retromer c ...... late endosomal tubule dynamics
@nl
P2093
P2860
P921
P3181
P356
P1476
The cargo-selective retromer c ...... late endosomal tubule dynamics
@en
P2093
Caroline Freeman
Matthew N J Seaman
Michael E Harbour
Robin Antrobus
Sophia Y A Breusegem
P2860
P304
P3181
P356
10.1242/JCS.071472
P407
P50
P577
2010-10-05T00:00:00Z