Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35
about
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIαVARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surfaceIdentification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recyclingCOMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7AEndosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromerA mechanism for retromer endosomal coat complex assembly with cargoRegulation of WASH-dependent actin polymerization and protein trafficking by ubiquitinationA global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transportRME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation.Role of the Retromer Complex in Neurodegenerative DiseasesThe retromer complex - endosomal protein recycling and beyondCapping protein regulators fine-tune actin assembly dynamicsActin polymerization controls the organization of WASH domains at the surface of endosomesThe spectrum of KIAA0196 variants, and characterization of a murine knockout: implications for the mutational mechanism in hereditary spastic paraplegia type SPG8.Intracellular Transport of Vaccinia Virus in HeLa Cells Requires WASH-VPEF/FAM21-Retromer Complexes and Recycling Molecules Rab11 and Rab22.ER contact sites define the position and timing of endosome fissionBiogenesis of endosome-derived transport carriers.Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein AggregationRetromer-mediated endosomal protein sorting: all WASHed up!Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell primingWASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector functionCCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDLMutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagyWash functions downstream of Rho1 GTPase in a subset of Drosophila immune cell developmental migrations.BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling EndosomesA CDC25 family protein phosphatase gates cargo recognition by the Vps26 retromer subunit.Expansion of biological pathways based on evolutionary inferenceRetromer: a master conductor of endosome sorting.Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndromeLemur Tyrosine Kinase 2, a novel target in prostate cancer therapyNuclear FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells.Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.A Novel PDZ Domain Interaction Mediates the Binding between Human Papillomavirus 16 L2 and Sorting Nexin 27 and Modulates Virion TraffickingTrafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks.VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.Cellular functions of WASP family proteins at a glance.VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1ARP2/3 localization in Arabidopsis leaf pavement cells: a diversity of intracellular pools and cytoskeletal interactionsA defect in the retromer accessory protein, SNX27, manifests by infantile myoclonic epilepsy and neurodegeneration.
P2860
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P2860
Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35
description
2012 nî lūn-bûn
@nan
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Recruitment of the endosomal W ...... to the retromer protein Vps35
@ast
Recruitment of the endosomal W ...... to the retromer protein Vps35
@en
Recruitment of the endosomal W ...... to the retromer protein Vps35
@en-gb
Recruitment of the endosomal W ...... to the retromer protein Vps35
@nl
type
label
Recruitment of the endosomal W ...... to the retromer protein Vps35
@ast
Recruitment of the endosomal W ...... to the retromer protein Vps35
@en
Recruitment of the endosomal W ...... to the retromer protein Vps35
@en-gb
Recruitment of the endosomal W ...... to the retromer protein Vps35
@nl
prefLabel
Recruitment of the endosomal W ...... to the retromer protein Vps35
@ast
Recruitment of the endosomal W ...... to the retromer protein Vps35
@en
Recruitment of the endosomal W ...... to the retromer protein Vps35
@en-gb
Recruitment of the endosomal W ...... to the retromer protein Vps35
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Recruitment of the endosomal W ...... to the retromer protein Vps35
@en
P2093
Matthew N J Seaman
Michael E Harbour
Sophia Y Breusegem
P2860
P304
P3181
P356
10.1042/BJ20111761
P407
P577
2012-02-15T00:00:00Z