A FAM21-containing WASH complex regulates retromer-dependent sorting
about
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIαRecruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surfaceThe Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migrationWASH and the Arp2/3 complex regulate endosome shape and trafficking.The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamicsSNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors.Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recyclingCOMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7AStructure and control of the actin regulatory WAVE complexEndosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromerEndosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexesWASH inhibits autophagy through suppression of Beclin 1 ubiquitinationRegulation of WASH-dependent actin polymerization and protein trafficking by ubiquitinationGadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complexRME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation.The Pfam protein families databaseWASP family proteins: their evolution and its physiological implications.Regulation of actin nucleation and autophagosome formationRole of the Retromer Complex in Neurodegenerative DiseasesThe retromer complex in development and diseaseActin nucleators in the nucleus: an emerging themeThe retromer complex - endosomal protein recycling and beyondEndosome maturationCapping protein regulators fine-tune actin assembly dynamicsUnder lock and key: spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processesFunction and regulation of the endosomal fusion and fission machineriesPhosphoinositides in the mammalian endo-lysosomal networkActin polymerization controls the organization of WASH domains at the surface of endosomesThe spectrum of KIAA0196 variants, and characterization of a murine knockout: implications for the mutational mechanism in hereditary spastic paraplegia type SPG8.OCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates.PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.Intracellular Transport of Vaccinia Virus in HeLa Cells Requires WASH-VPEF/FAM21-Retromer Complexes and Recycling Molecules Rab11 and Rab22.ER contact sites define the position and timing of endosome fissionCLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic traffickingCARMIL leading edge localization depends on a non-canonical PH domain and dimerizationBiogenesis of endosome-derived transport carriers.Rab GTPase regulation of retromer-mediated cargo export during endosome maturation.Fission of SNX-BAR-coated endosomal retrograde transport carriers is promoted by the dynamin-related protein Vps1.
P2860
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P2860
A FAM21-containing WASH complex regulates retromer-dependent sorting
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A FAM21-containing WASH complex regulates retromer-dependent sorting
@ast
A FAM21-containing WASH complex regulates retromer-dependent sorting
@en
A FAM21-containing WASH complex regulates retromer-dependent sorting
@en-gb
A FAM21-containing WASH complex regulates retromer-dependent sorting
@nl
type
label
A FAM21-containing WASH complex regulates retromer-dependent sorting
@ast
A FAM21-containing WASH complex regulates retromer-dependent sorting
@en
A FAM21-containing WASH complex regulates retromer-dependent sorting
@en-gb
A FAM21-containing WASH complex regulates retromer-dependent sorting
@nl
prefLabel
A FAM21-containing WASH complex regulates retromer-dependent sorting
@ast
A FAM21-containing WASH complex regulates retromer-dependent sorting
@en
A FAM21-containing WASH complex regulates retromer-dependent sorting
@en-gb
A FAM21-containing WASH complex regulates retromer-dependent sorting
@nl
P2860
P921
P3181
P1433
P1476
A FAM21-containing WASH complex regulates retromer-dependent sorting
@en
P2093
Daniel D Billadeau
Timothy S Gomez
P2860
P304
P3181
P356
10.1016/J.DEVCEL.2009.09.009
P407
P577
2009-11-01T00:00:00Z