Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage
about
APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachmentFcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exitNuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitorMaintaining Genome Stability in Defiance of Mitotic DNA DamageInsights into APC/C: from cellular function to diseases and therapeuticsAntiproliferative Fate of the Tetraploid Formed after Mitotic Slippage and Its Promotion; A Novel Target for Cancer Therapy Based on Microtubule PoisonsContribution of the Type II Chaperonin, TRiC/CCT, to OncogenesisTargeting the Mitotic Catastrophe Signaling Pathway in CancerK11-linked ubiquitin chains as novel regulators of cell divisionTargeting the ubiquitin pathway for cancer treatmentDNA damage associated with mitosis and cytokinesis failureFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisThe 3' untranslated region of the cyclin B mRNA is not sufficient to enhance the synthesis of cyclin B during a mitotic block in human cellsAtomic structure of the APC/C and its mechanism of protein ubiquitination.Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability.The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.A decade of the anaphase-promoting complex in the nervous systemSpatiotemporal regulation of the anaphase-promoting complex in mitosisUSP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesisA modified HSP70 inhibitor shows broad activity as an anticancer agent.Microtubule-dependent regulation of mitotic protein degradation.Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification.Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.Molecular mechanism of APC/C activation by mitotic phosphorylation.Cdc20: a potential novel therapeutic target for cancer treatmentInhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads.Precocious centriole disengagement and centrosome fragmentation induced by mitotic delayAPC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.Mechanisms promoting escape from mitotic stress-induced tumor cell death.Targeting the anaphase-promoting complex/cyclosome (APC/C)- bromodomain containing 7 (BRD7) pathway for human osteosarcoma.The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2.The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium.Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a.Cohesion fatigue explains why pharmacological inhibition of the APC/C induces a spindle checkpoint-dependent mitotic arrestAPC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage.Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet)Mutual regulation between the spindle checkpoint and APC/C.Targeting Cdc20 as a novel cancer therapeutic strategy.Killing cells by targeting mitosis
P2860
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P2860
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Pharmacologic inhibition of th ...... the absence of spindle damage
@ast
Pharmacologic inhibition of th ...... the absence of spindle damage
@en
Pharmacologic inhibition of th ...... the absence of spindle damage
@en-gb
Pharmacologic inhibition of th ...... the absence of spindle damage
@nl
type
label
Pharmacologic inhibition of th ...... the absence of spindle damage
@ast
Pharmacologic inhibition of th ...... the absence of spindle damage
@en
Pharmacologic inhibition of th ...... the absence of spindle damage
@en-gb
Pharmacologic inhibition of th ...... the absence of spindle damage
@nl
prefLabel
Pharmacologic inhibition of th ...... the absence of spindle damage
@ast
Pharmacologic inhibition of th ...... the absence of spindle damage
@en
Pharmacologic inhibition of th ...... the absence of spindle damage
@en-gb
Pharmacologic inhibition of th ...... the absence of spindle damage
@nl
P2093
P2860
P921
P3181
P1433
P1476
Pharmacologic inhibition of th ...... the absence of spindle damage
@en
P2093
Dong-Chan Oh
Frederic Sigoillot
Gregory D Cuny
Kathleen L Pfaff
Nathaniel Hathaway
Nevena Dimova
Randall W King
Sungwoon Choi
P2860
P304
P3181
P356
10.1016/J.CCR.2010.08.010
P407
P577
2010-10-01T00:00:00Z