E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
about
The function of APC/CCdh1 in cell cycle and beyondRole of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosomeEmi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitorPharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damageThe tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complexPlk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1The decision to enter mitosis: feedback and redundancy in the mitotic entry networkDifferential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exitRegulation of late G1/S phase transition and APC Cdh1 by reactive oxygen speciesSystematic analysis and nomenclature of mammalian F-box proteinsMammalian Cdh1/Fzr mediates its own degradationThe ubiquitin proteasome system in neuropathologyDeregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerIdentification of Rab11 as a small GTPase binding protein for the Evi5 oncogeneProphase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1)The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human CancersRINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisThe Evi5 family in cellular physiology and pathologyHypersensitivity to DNA damage in antephase as a safeguard for genome stability.The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylationElectron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdownThe predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradationPseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation.Mechanisms of pseudosubstrate inhibition of the anaphase promoting complex by Acm1.Inhibition of APCCdh1 activity by Cdh1/Acm1/Bmh1 ternary complex formation.Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathwayNuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylationThe SCF ubiquitin ligase: insights into a molecular machinePhospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage responseThe ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transitionTumor suppressors and cell-cycle proteins in lung cancerMouse emi1 has an essential function in mitotic progression during early embryogenesisCdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicityFunctional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytesThe anaphase promoting complex/cyclosome: a machine designed to destroyAurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.The APC/C inhibitor, Emi1, is essential for prevention of rereplication
P2860
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P2860
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
@ast
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
@en
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
@en-gb
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
@nl
type
label
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
@ast
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
@en
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
@en-gb
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
@nl
prefLabel
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
@ast
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
@en
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
@en-gb
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
@nl
P2093
P3181
P356
P1433
P1476
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
@en
P2093
Claus S Sørensen
Jerry Y Hsu
Julie D R Reimann
Peter K Jackson
P2888
P304
P3181
P356
10.1038/NCB785
P407
P50
P577
2002-05-01T00:00:00Z
P5875
P6179
1050808058