MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks
about
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repairBreast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repairEpigenetic virtues of chromodomainsSolution Structure of the mSin3A PAH2–Pf1 SID1 Complex: A Mad1/Mxd1-Like Interaction Disrupted by MRG15 in the Rpd3S/Sin3S ComplexStructural Basis for Molecular Interactions Involving MRG Domains: Implications in Chromatin BiologyPALB2: the hub of a network of tumor suppressors involved in DNA damage responsesCharacterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomicsExploring the link between MORF4L1 and risk of breast cancer.Male fertility defect associated with disrupted BRCA1-PALB2 interaction in micePALB2/FANCN: recombining cancer and Fanconi anemia.Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complexsiRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations.Condensin II Regulates Interphase Chromatin Organization Through the Mrg-Binding Motif of Cap-H2.Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.Connecting chromatin modifying factors to DNA damage response.Prevalence of PALB2 mutations in Australasian multiple-case breast cancer familiesPALB2 and breast cancer: ready for clinical translation!MRG15 is required for pre-mRNA splicing and spermatogenesis.Structural studies on MRG701 chromodomain reveal a novel dimerization interface of MRG proteins in green plants.Hypersensitivities for acetaldehyde and other agents among cancer cells null for clinically relevant Fanconi anemia genes.Physiological roles of class I HDAC complex and histone demethylase.Cross-talk between the H3K36me3 and H4K16ac histone epigenetic marks in DNA double-strand break repair.The Role of PALB2 in the DNA Damage Response and Cancer Predisposition.Structural Basis for Multi-specificity of MRG Domains.MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress.A new companion of elongating RNA Polymerase II: TINTIN, an independent sub-module of NuA4/TIP60 for nucleosome transactions.Loss of the chromatin regulator MRG15 limits neural stem/progenitor cell proliferation via increased expression of the p21 Cdk inhibitor.Perturbation of PALB2 function by the T413S mutation found in small cell lung cancer.BRCA1 alterations with additional defects in DNA damage response genes may confer chemoresistance to BRCA-like breast cancers treated with neoadjuvant chemotherapy.Analysis of PALB2 in a cohort of Italian breast cancer patients: identification of a novel PALB2 truncating mutation.
P2860
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P2860
MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
MRG15 binds directly to PALB2 ...... d repair of chromosomal breaks
@ast
MRG15 binds directly to PALB2 ...... d repair of chromosomal breaks
@en
MRG15 binds directly to PALB2 ...... d repair of chromosomal breaks
@nl
type
label
MRG15 binds directly to PALB2 ...... d repair of chromosomal breaks
@ast
MRG15 binds directly to PALB2 ...... d repair of chromosomal breaks
@en
MRG15 binds directly to PALB2 ...... d repair of chromosomal breaks
@nl
prefLabel
MRG15 binds directly to PALB2 ...... d repair of chromosomal breaks
@ast
MRG15 binds directly to PALB2 ...... d repair of chromosomal breaks
@en
MRG15 binds directly to PALB2 ...... d repair of chromosomal breaks
@nl
P2093
P2860
P921
P3181
P356
P1476
MRG15 binds directly to PALB2 ...... d repair of chromosomal breaks
@en
P2093
Kaori Shinmyozu
Noriyo Hayakawa
Paul R Andreassen
Tomohiro Hayakawa
Yasuko Ohtani
P2860
P304
P3181
P356
10.1242/JCS.060178
P407
P577
2010-04-01T00:00:00Z