PALB2 regulates recombinational repair through chromatin association and oligomerization
about
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repairMRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaksRegulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forksPALB2: the hub of a network of tumor suppressors involved in DNA damage responsesMitotic homologous recombination maintains genomic stability and suppresses tumorigenesisCooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombinationRare germline mutations in PALB2 and breast cancer risk: a population-based study.c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells.A novel germline PALB2 deletion in Polish breast and ovarian cancer patientsCancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motifMale fertility defect associated with disrupted BRCA1-PALB2 interaction in miceBreast-cancer risk in families with mutations in PALB2Structure and mechanism of action of the BRCA2 breast cancer tumor suppressorMutations in BRCA2 and PALB2 in male breast cancer cases from the United StatesAnalysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer casesCritical roles of ring finger protein RNF8 in replication stress responses.BRCA1 tumor suppressor network: focusing on its tail.Homologous recombination and its regulationATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response.MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombinationPrevalence of PALB2 mutations in Australasian multiple-case breast cancer familiesFocus on histone variant H2AX: to be or not to be.PALB2 and breast cancer: ready for clinical translation!MRG15 is a novel PALB2-interacting factor involved in homologous recombination.Assembly of checkpoint and repair machineries at DNA damage sites.Collaboration and competition between DNA double-strand break repair pathways.Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer.Time to incorporate germline multigene panel testing into breast and ovarian cancer patient care.The Role of PALB2 in the DNA Damage Response and Cancer Predisposition.Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress.PALB2 self-interaction controls homologous recombination.PARP-mediated repair, homologous recombination, and back-up non-homologous end joining-like repair of single-strand nicksCharacterization of a novel germline PALB2 duplication in a hereditary breast and ovarian cancer family.Perturbation of PALB2 function by the T413S mutation found in small cell lung cancer.The role of Rak in the regulation of stability and function of BRCA1.Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations.Association of PALB2 sequence variants with the risk of early-onset breast cancer in patients from Turkey.Heterozygous mutations in the PALB2 hereditary breast cancer predisposition gene impact on the three-dimensional nuclear organization of patient-derived cell lines.
P2860
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P2860
PALB2 regulates recombinational repair through chromatin association and oligomerization
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
PALB2 regulates recombinational repair through chromatin association and oligomerization
@ast
PALB2 regulates recombinational repair through chromatin association and oligomerization
@en
PALB2 regulates recombinational repair through chromatin association and oligomerization
@en-gb
PALB2 regulates recombinational repair through chromatin association and oligomerization
@nl
type
label
PALB2 regulates recombinational repair through chromatin association and oligomerization
@ast
PALB2 regulates recombinational repair through chromatin association and oligomerization
@en
PALB2 regulates recombinational repair through chromatin association and oligomerization
@en-gb
PALB2 regulates recombinational repair through chromatin association and oligomerization
@nl
prefLabel
PALB2 regulates recombinational repair through chromatin association and oligomerization
@ast
PALB2 regulates recombinational repair through chromatin association and oligomerization
@en
PALB2 regulates recombinational repair through chromatin association and oligomerization
@en-gb
PALB2 regulates recombinational repair through chromatin association and oligomerization
@nl
P2093
P2860
P921
P356
P1476
PALB2 regulates recombinational repair through chromatin association and oligomerization
@en
P2093
Junjie Chen
Michael S Y Huen
Yongyou Zhu
P2860
P304
P356
10.1074/JBC.M109.016717
P407
P577
2009-07-03T00:00:00Z