ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair
about
The Response to Oxidative DNA Damage in Neurons: Mechanisms and DiseaseBase Excision Repair, a Pathway Regulated by Posttranslational ModificationsATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cellsNon-homologous end joining: emerging themes and unanswered questions.Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a timeInterplay of DNA damage and cell cycle signaling at the level of human replication protein ADNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes.Non-homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process.Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions.Mutations in PNKP cause recessive ataxia with oculomotor apraxia type 4.The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.DNA end processing by polynucleotide kinase/phosphatase.Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress.The ATM signaling network in development and disease.Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining.Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay.Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.Topoisomerase-mediated chromosomal break repair: an emerging player in many games.The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair.Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repairSUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability.Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest.Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair.Persistent 3'-phosphate termini and increased cytotoxicity of radiomimetic DNA double-strand breaks in cells lacking polynucleotide kinase/phosphatase despite presence of an alternative 3'-phosphatase.
P2860
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P2860
ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
ATM-mediated phosphorylation o ...... DNA double-strand break repair
@ast
ATM-mediated phosphorylation o ...... DNA double-strand break repair
@en
ATM-mediated phosphorylation o ...... DNA double-strand break repair
@en-gb
ATM-mediated phosphorylation o ...... DNA double-strand break repair
@nl
type
label
ATM-mediated phosphorylation o ...... DNA double-strand break repair
@ast
ATM-mediated phosphorylation o ...... DNA double-strand break repair
@en
ATM-mediated phosphorylation o ...... DNA double-strand break repair
@en-gb
ATM-mediated phosphorylation o ...... DNA double-strand break repair
@nl
prefLabel
ATM-mediated phosphorylation o ...... DNA double-strand break repair
@ast
ATM-mediated phosphorylation o ...... DNA double-strand break repair
@en
ATM-mediated phosphorylation o ...... DNA double-strand break repair
@en-gb
ATM-mediated phosphorylation o ...... DNA double-strand break repair
@nl
P2093
P2860
P356
P1433
P1476
ATM-mediated phosphorylation o ...... DNA double-strand break repair
@en
P2093
Cecilia E Ström
David J Chen
Gilad Mass
Hava Segal-Raz
Keren Baranes-Bachar
Mickey C-T Hu
Shelly Ziv-Lehrman
Shih-Ya Wang
Yaniv Lerenthal
Yosef Shiloh
P2860
P356
10.1038/EMBOR.2011.96
P407
P577
2011-07-01T00:00:00Z