Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
about
miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifsmiRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOTIdentification of novel NPRAP/δ-catenin-interacting proteins and the direct association of NPRAP with dynamin 2The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targetsPhosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fateGW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylationStructural features of Argonaute-GW182 protein interactionsThe organization and regulation of mRNA-protein complexesThe molecular mechanism of translational control via the communication between the microRNA pathway and RNA-binding proteinsThe role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnoverThe TAL effector PthA4 interacts with nuclear factors involved in RNA-dependent processes including a HMG protein that selectively binds poly(U) RNAAnti-PABPC1 co-immunoprecipitation for examining the miRNAs directly targeting the 3'-UTR of EED mRNAPlakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteinsDeadenylation of mRNA by the CCR4-NOT complex in Drosophila: molecular and developmental aspects.The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.The complexity of miRNA-mediated repressionMammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencingThe Ataxin-2 protein is required for microRNA function and synapse-specific long-term olfactory habituation.miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components.A comprehensively molecular haplotype-resolved genome of a European individualStability of a long noncoding viral RNA depends on a 9-nt core element at the RNA 5' end to interact with viral ORF57 and cellular PABPC1.Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish.PABPC1 exerts carcinogenesis in gastric carcinoma by targeting miR-34c.The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes.Early origin and adaptive evolution of the GW182 protein family, the key component of RNA silencing in animals.A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails.A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs.Capturing microRNA targets using an RNA-induced silencing complex (RISC)-trap approach.Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA.RIPSeeker: a statistical package for identifying protein-associated transcripts from RIP-seq experiments.Nucleolin mediates microRNA-directed CSF-1 mRNA deadenylation but increases translation of CSF-1 mRNA.Coordinated Regulation of Cap-Dependent Translation and MicroRNA Function by Convergent Signaling Pathways.MicroRNA-mediated gene silencing: are we close to a unifying model?RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein.The coupled and uncoupled mechanisms by which trans-acting factors regulate mRNA stability and translation.Strong reduction of AGO2 expression in melanoma and cellular consequences.The Anopheles gambiae alpha-tubulin-1b promoter directs neuronal, testes and developing imaginal tissue specific expression and is a sensitive enhancer detector.PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro.Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.
P2860
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P2860
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
@ast
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
@en
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
@en-gb
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
@nl
type
label
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
@ast
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
@en
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
@en-gb
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
@nl
prefLabel
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
@ast
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
@en
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
@en-gb
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
@nl
P2860
P50
P3181
P356
P1433
P1476
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
@en
P2093
Latifa Zekri
Susanne Heimstädt
P2860
P304
P3181
P356
10.1038/EMBOJ.2010.274
P407
P5008
P577
2010-12-15T00:00:00Z