mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes
about
Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundancemiRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifsmiRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOTCCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cellsProteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cellsThe structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complexThe human Pat1b protein: a novel mRNA deadenylation factor identified by a new immunoprecipitation techniqueStructural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding proteinThe interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targetsTwo PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencingMultiple mRNA decapping enzymes in mammalian cellsThe C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencingN6-methyladenosine-dependent regulation of messenger RNA stabilityMammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylationThe Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferationThe C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteinsAgo2/miRISC-mediated inhibition of CBP80/20-dependent translation and thereby abrogation of nonsense-mediated mRNA decay require the cap-associating activity of Ago2GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylationLet-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free systemATP-dependent human RISC assembly pathwaysThe Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescenceN(6)-methyladenosine Modulates Messenger RNA Translation EfficiencyLIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencingThe role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viabilitymiRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decayExperimental strategies for microRNA target identificationThe miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseasesKinetic signatures of microRNA modes of actionPost-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153The RNA-induced silencing complex: a versatile gene-silencing machineDeadenylation of maternal mRNAs mediated by miR-427 in Xenopus laevis embryosAn expanded seed sequence definition accounts for full regulation of the hid 3' UTR by bantam miRNADeadenylation is a widespread effect of miRNA regulationHuman TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylationMicroRNAs: Key Regulators in the Central Nervous System and Their Implication in Neurological DiseasesTiny giants of gene regulation: experimental strategies for microRNA functional studiesRNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal FunctionsPost-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virusBiogenesis, turnover, and mode of action of plant microRNAsMechanisms of deadenylation-dependent decay
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P2860
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes
description
2006 nî lūn-bûn
@nan
2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
mRNA degradation by miRNAs and ...... DCP1:DCP2 decapping complexes
@ast
mRNA degradation by miRNAs and ...... DCP1:DCP2 decapping complexes
@en
mRNA degradation by miRNAs and ...... DCP1:DCP2 decapping complexes
@nl
type
label
mRNA degradation by miRNAs and ...... DCP1:DCP2 decapping complexes
@ast
mRNA degradation by miRNAs and ...... DCP1:DCP2 decapping complexes
@en
mRNA degradation by miRNAs and ...... DCP1:DCP2 decapping complexes
@nl
prefLabel
mRNA degradation by miRNAs and ...... DCP1:DCP2 decapping complexes
@ast
mRNA degradation by miRNAs and ...... DCP1:DCP2 decapping complexes
@en
mRNA degradation by miRNAs and ...... DCP1:DCP2 decapping complexes
@nl
P2860
P50
P3181
P356
P1433
P1476
mRNA degradation by miRNAs and ...... DCP1:DCP2 decapping complexes
@en
P2860
P304
P3181
P356
10.1101/GAD.1424106
P407
P577
2006-07-15T00:00:00Z