ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2
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A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicityGTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamilyAn early endosome regulator, Rab5b, is an LRRK2 kinase substrateLRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson diseaseMolecular Machines Determining the Fate of Endocytosed Synaptic Vesicles in Nerve TerminalsCurrent understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor designHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsRevisiting the Roco G-protein cyclePhosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPasesInnate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infectionPhosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.ARFGAP1 is dynamically associated with lipid droplets in hepatocytesLRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization.Targeting GTPases in Parkinson's disease: comparison to the historic path of kinase drug discovery and perspectivesIdentification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3) Mutants in Drosophila melanogaster.Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expressionInterplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective AutophagyCellular effects of LRRK2 mutations.14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease.Contribution of GTPase activity to LRRK2-associated Parkinson diseaseLeucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease.Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.The GTPase function of LRRK2.LRRK2 and vesicle trafficking.Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation.LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesisInteraction of LRRK2 with kinase and GTPase signaling cascadesLRRK2 pathobiology in Parkinson's disease.LRRK2 Pathways Leading to Neurodegeneration.LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.Models of LRRK2-Associated Parkinson's Disease.Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations.
P2860
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P248
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P2860
ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2
@ast
ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2
@en
ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2
@en-gb
ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2
@nl
type
label
ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2
@ast
ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2
@en
ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2
@en-gb
ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2
@nl
prefLabel
ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2
@ast
ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2
@en
ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2
@en-gb
ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2
@nl
P2093
P2860
P921
P3181
P1476
ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2
@en
P2093
Changqing Yuan
Valina L Dawson
Yulan Xiong
P2860
P304
P3181
P356
10.1523/JNEUROSCI.4566-11.2012
P407
P577
2012-03-14T00:00:00Z