ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2 - Test2 - elhamkhani - TriplyDB

ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2

ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2

http://www.wikidata.org/entity/Q24307742

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A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2 Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7 Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily An early endosome regulator, Rab5b, is an LRRK2 kinase substrate LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25 Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease Molecular Machines Determining the Fate of Endocytosed Synaptic Vesicles in Nerve Terminals Current understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor design Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications Revisiting the Roco G-protein cycle Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.ARFGAP1 is dynamically associated with lipid droplets in hepatocytes LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization.Targeting GTPases in Parkinson's disease: comparison to the historic path of kinase drug discovery and perspectives Identification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3) Mutants in Drosophila melanogaster.Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy Cellular effects of LRRK2 mutations.14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease.Contribution of GTPase activity to LRRK2-associated Parkinson disease Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease.Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.The GTPase function of LRRK2.LRRK2 and vesicle trafficking.Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation.LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis Interaction of LRRK2 with kinase and GTPase signaling cascades LRRK2 pathobiology in Parkinson's disease.LRRK2 Pathways Leading to Neurodegeneration.LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.Models of LRRK2-Associated Parkinson's Disease.Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations.

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P2860

ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2

http://www.wikidata.org/entity/Q24307742

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2012 nî lūn-bûn

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2012 թուականի Մարտին հրատարակուած գիտական յօդուած

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2012 թվականի մարտին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2

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ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2

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ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2

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ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2

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ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2

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ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2

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ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2

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ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2

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ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2

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ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2

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ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2

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ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2

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JNEUROSCI.4566-11.2012

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Journal of Neuroscience

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ArfGAP1 is a GTPase activating ...... regulation of ArfGAP1 by LRRK2

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Changqing Yuan

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Rong Chen

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Valina L Dawson

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Yulan Xiong

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P2860

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

Kinase activity of mutant LRRK2 mediates neuronal toxicity

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

LRRK2 regulates synaptic vesicle endocytosis

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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3877-86

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scholarly article

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1673655

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10.1523/JNEUROSCI.4566-11.2012

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Leucine-rich repeat kinase 2

ADP ribosylation factor GTPase activating protein 1

ADP-ribosylation factor GTPase activating protein 1

Leucine rich repeat kinase 2

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3319331

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