Identification and characterization of the human ARD1-NATH protein acetyltransferase complex
about
NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregationComposition and biological significance of the human Nα-terminal acetyltransferasesA novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1)The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent mannerHuman Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activityKnockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localizationCharacterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferaseArrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinaseThe chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregationCharacterization of the native and fibrillar conformation of the human Nalpha-acetyltransferase ARD1N-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effectsStructure of a Ternary Naa50p (NAT5/SAN) N-terminal Acetyltransferase Complex Reveals the Molecular Basis for Substrate-specific AcetylationMolecular basis for N-terminal acetylation by the heterodimeric NatA complexN-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases.Protein N-terminal acetyltransferases act as N-terminal propionyltransferases in vitro and in vivo.Cloning, characterization, and expression analysis of the novel acetyltransferase retrogene Ard1b in the mouseUsing VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiencyInhibition of STAT5a by Naa10p contributes to decreased breast cancer metastasisDe novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and femalesNuclear translocation of hARD1 contributes to proper cell cycle progressionBiochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defectsPhosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradationArrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIFExpression, crystallization and preliminary X-ray crystallographic analyses of two N-terminal acetyltransferase-related proteins from Thermoplasma acidophilumARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathwayInteraction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alphaDrosophila variable nurse cells encodes arrest defective 1 (ARD1), the catalytic subunit of the major N-terminal acetyltransferase complexPurified recombinant hARD1 does not catalyse acetylation of Lys532 of HIF-1alpha fragments in vitroAn acetylase with relaxed specificity catalyses protein N-terminal acetylation in Sulfolobus solfataricusA Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutantA splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndromeProteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p as the post-translational actin N(alpha)-acetyltransferaseCrystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific AcetylationThe biological functions of Naa10 - From amino-terminal acetylation to human diseaseNaa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion.The protein Nalpha-terminal acetyltransferase hNaa10p (hArd1) is phosphorylated in HEK293 cells.Protein N-terminal acetylation: NAT 2007-2008 Symposia.A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substratesCharacterization of the human Nalpha-terminal acetyltransferase B enzymatic complex.
P2860
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P2860
Identification and characterization of the human ARD1-NATH protein acetyltransferase complex
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
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2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Identification and characteriz ...... tein acetyltransferase complex
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Identification and characteriz ...... tein acetyltransferase complex
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Identification and characteriz ...... tein acetyltransferase complex
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Identification and characteriz ...... tein acetyltransferase complex
@nl
type
label
Identification and characteriz ...... tein acetyltransferase complex
@ast
Identification and characteriz ...... tein acetyltransferase complex
@en
Identification and characteriz ...... tein acetyltransferase complex
@en-gb
Identification and characteriz ...... tein acetyltransferase complex
@nl
prefLabel
Identification and characteriz ...... tein acetyltransferase complex
@ast
Identification and characteriz ...... tein acetyltransferase complex
@en
Identification and characteriz ...... tein acetyltransferase complex
@en-gb
Identification and characteriz ...... tein acetyltransferase complex
@nl
P2093
P2860
P921
P3181
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Identification and characteriz ...... tein acetyltransferase complex
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P2093
Christian Baldersheim
Dave Anderson
Johan R Lillehaug
Michel Lanotte
P2860
P304
P3181
P356
10.1042/BJ20041071
P407
P577
2005-03-15T00:00:00Z