FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress
about
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cellsRPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage responseBalancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Synergistic effect of two E2 ubiquitin conjugating enzymes in SCF(hFBH1) catalyzed polyubiquitination.Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.DNA helicases involved in DNA repair and their roles in cancerEXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cells.Small molecule therapeutics targeting F-box proteins in cancer.Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteinsFBH1 protects melanocytes from transformation and is deregulated in melanomasPIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damageRare coding variants and breast cancer risk: evaluation of susceptibility Loci identified in genome-wide association studies.Recent advances in SCF ubiquitin ligase complex: Clinical implicationsCadmium-induced apoptosis of Siberian tiger fibroblasts via disrupted intracellular homeostasisDeath becomes her: FBH1, DNA damage and apoptosis.SLX4 gains weight with SUMO in genome maintenance.FBH1: a new checkpoint factor.Cadmium stimulates mouse skin fibroblast apoptosis by affecting intracellular homeostasis.The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation.
P2860
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P2860
FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
FBH1 promotes DNA double-stran ...... onse to DNA replication stress
@ast
FBH1 promotes DNA double-stran ...... onse to DNA replication stress
@en
FBH1 promotes DNA double-stran ...... onse to DNA replication stress
@en-gb
FBH1 promotes DNA double-stran ...... onse to DNA replication stress
@nl
type
label
FBH1 promotes DNA double-stran ...... onse to DNA replication stress
@ast
FBH1 promotes DNA double-stran ...... onse to DNA replication stress
@en
FBH1 promotes DNA double-stran ...... onse to DNA replication stress
@en-gb
FBH1 promotes DNA double-stran ...... onse to DNA replication stress
@nl
prefLabel
FBH1 promotes DNA double-stran ...... onse to DNA replication stress
@ast
FBH1 promotes DNA double-stran ...... onse to DNA replication stress
@en
FBH1 promotes DNA double-stran ...... onse to DNA replication stress
@en-gb
FBH1 promotes DNA double-stran ...... onse to DNA replication stress
@nl
P2093
P2860
P50
P921
P3181
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P1476
FBH1 promotes DNA double-stran ...... onse to DNA replication stress
@en
P2093
Carl L Schildkraut
Carl Schildkraut
Lukas Cermak
Patrick Sung
Yeon-Tae Jeong
P2860
P3181
P356
10.1083/JCB.201209002
P407
P5008
P577
2013-01-21T00:00:00Z