sameAs
The F-box protein family.Identification of a family of human F-box proteinsInsights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complexRole of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosomeStructure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complexSCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint responseSCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteinsSCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myelomaFBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stressPCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpointCyclin A is required at two points in the human cell cycleUSP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repairThe ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survivalSCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradationStructural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligaseFBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascadeNovel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functionsOncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancerSystematic analysis and nomenclature of mammalian F-box proteinsSpecific small molecule inhibitors of Skp2-mediated p27 degradationRole of the F-box protein Skp2 in lymphomagenesisClinical relevance of SKP2 alterations in metastatic melanomaControl of cell growth by the SCF and APC/C ubiquitin ligasesDeregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerHuman cyclin E, a nuclear protein essential for the G1-to-S phase transitionRole of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradationSCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocketThe human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivoDegradation of Cdc25A by beta-TrCP during S phase and in response to DNA damageRole of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phaseThree different binding sites of Cks1 are required for p27-ubiquitin ligationControl of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligaseCyclin D1 is a nuclear protein required for cell cycle progression in G1S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growthControl of chromosome stability by the beta-TrCP-REST-Mad2 axisThe SCF ubiquitin ligase: insights into a molecular machinebetaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis
P50
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P50
description
Italian-American biochemist and cancer biologist
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onderzoeker
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հետազոտող
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name
Michele Pagano
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Michele Pagano
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Michele Pagano
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Michele Pagano
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Michele Pagano
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Michele Pagano
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Michele Pagano
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Michele Pagano
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M Pagano
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M. Pagano
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Pagano M
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Pagano M.
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Michele Pagano
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Michele Pagano
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Michele Pagano
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Michele Pagano
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P106
P21
P31
P496
0000-0003-3210-2442