Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities - Test2 - elhamkhani - TriplyDB

Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

http://www.wikidata.org/entity/Q24314262

about

Inhibition of homologous recombination by the PCNA-interacting protein PARI FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51 Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase.FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells The Regulation of DNA Damage Tolerance by Ubiquitin and Ubiquitin-Like Modifiers From yeast to mammals: recent advances in genetic control of homologous recombination Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity Regulation and roles of Cdc7 kinase under replication stress.Regulation of homologous recombination in eukaryotes.Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1 RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination.Helicase-inactivating mutations as a basis for dominant negative phenotypes.Synthetic lethality between gene defects affecting a single non-essential molecular pathway with reversible steps.Cell biology of mitotic recombination.Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.Rad51 paralogues Rad55-Rad57 balance the antirecombinase Srs2 in Rad51 filament formation.Protein degradation pathways regulate the functions of helicases in the DNA damage response and maintenance of genomic stability Homologous recombination and its regulation Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation Small molecule therapeutics targeting F-box proteins in cancer.The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis.FBH1 protects melanocytes from transformation and is deregulated in melanomas Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins.New histone supply regulates replication fork speed and PCNA unloading.Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing.Common Chemical Inductors of Replication Stress: Focus on Cell-Based Studies.Single-molecule sorting of DNA helicases.Replication fork reversal in eukaryotes: from dead end to dynamic response.Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance.Regulation of recombination and genomic maintenance.An Overview of the Molecular Mechanisms of Recombinational DNA Repair.Mammalian Fbh1 is important to restore normal mitotic progression following decatenation stress.Death becomes her: FBH1, DNA damage and apoptosis.Presynaptic filament dynamics in homologous recombination and DNA repair.A failure of meiotic chromosome segregation in a fbh1Delta mutant correlates with persistent Rad51-DNA associations.

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P2860

Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

http://www.wikidata.org/entity/Q24314262

description

2009 nî lūn-bûn

@nan

2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

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2009年論文

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2009年论文

@wuu

name

Human Fbh1 helicase contribute ...... nd anti-recombinase activities

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Human Fbh1 helicase contribute ...... nd anti-recombinase activities

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Human Fbh1 helicase contribute ...... nd anti-recombinase activities

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Human Fbh1 helicase contribute ...... nd anti-recombinase activities

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type

label

Human Fbh1 helicase contribute ...... nd anti-recombinase activities

@ast

Human Fbh1 helicase contribute ...... nd anti-recombinase activities

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Human Fbh1 helicase contribute ...... nd anti-recombinase activities

@en-gb

Human Fbh1 helicase contribute ...... nd anti-recombinase activities

@nl

prefLabel

Human Fbh1 helicase contribute ...... nd anti-recombinase activities

@ast

Human Fbh1 helicase contribute ...... nd anti-recombinase activities

@en

Human Fbh1 helicase contribute ...... nd anti-recombinase activities

@en-gb

Human Fbh1 helicase contribute ...... nd anti-recombinase activities

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P1433

Journal of Cell Biology

P1476

Human Fbh1 helicase contribute ...... nd anti-recombinase activities

@en

P2093

Christoffel Dinant

http://www.w3.org/2001/XMLSchema#string

Jacob Falck

http://www.w3.org/2001/XMLSchema#string

Jannie Rendtlew Danielsen

http://www.w3.org/2001/XMLSchema#string

Martin Mistrik

http://www.w3.org/2001/XMLSchema#string

Niels Mailand

http://www.w3.org/2001/XMLSchema#string

P2860

Interplay between human DNA repair proteins at a unique double-strand break in vivo

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

RTEL1 maintains genomic stability by suppressing homologous recombination

Human CtIP promotes DNA end resection

RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments

The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

Mechanism of homologous recombination: mediators and helicases take on regulatory functions

Regulation of replication fork progression through histone supply and demand

P304

655-63

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P31

scholarly article

P3181

849489

http://www.w3.org/2001/XMLSchema#string

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10.1083/JCB.200812138

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

186

http://www.w3.org/2001/XMLSchema#string

P50

P577

2009-09-07T00:00:00Z

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P5875

26795206

http://www.w3.org/2001/XMLSchema#string

P698

19736316

http://www.w3.org/2001/XMLSchema#string

P921

negative regulation of double-strand break repair via homologous recombination

F-box DNA helicase 1

P932

2742184

http://www.w3.org/2001/XMLSchema#string