The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
about
SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradationTIP120A associates with cullins and modulates ubiquitin ligase activityMammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.The role of microtubule-associated protein 1S in SOCS3 regulation of IL-6 signalingSuppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signalingThe E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteinsVHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligasesAnkyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradationAnkyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor IIPrinciples of interleukin (IL)-6-type cytokine signalling and its regulationRegulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardationSelective regulatory function of Socs3 in the formation of IL-17-secreting T cellsFunctional analysis of Asb-1 using genetic modification in micePlacental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligaseIdentification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complexActivation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complexThe HIV-1 Vif PPLP motif is necessary for human APOBEC3G binding and degradationTwo Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activitiesSignaling by STATsJanus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Negative regulation of cytokine signaling and immune responses by SOCS proteinsSystematic discovery of new recognition peptides mediating protein interaction networksWSB1: from homeostasis to hypoxiaSuppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-CellsUbiquitin signaling in immune responsesSOCS3: An essential physiological inhibitor of signaling by interleukin-6 and G-CSF family cytokinesThe role of suppressors of cytokine signalling in human neoplasmsHepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin LigaseSOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibitionSOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanismsSuppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistanceSHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptorSuppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signalingCish actively silences TCR signaling in CD8+ T cells to maintain tumor toleranceSignal transducer and activator of transcription 5A/B in prostate and breast cancersSOCS2 negatively regulates growth hormone action in vitro and in vivo
P2860
Q22001519-A6ECB5B6-2060-4621-97D9-C6E47B4012D9Q24296285-328C39C6-582F-4DDC-9C13-88856B9D4154Q24302474-DA653DA2-78A6-4A9C-958A-CC3DE5ECD851Q24316883-828B2A9C-2256-49FE-BD33-C5D1302A7471Q24321251-7E7018BB-EED5-455A-A540-4C21CCFD79CCQ24321847-C45EF1CB-B9FB-43C6-92A8-E7BE56DF7E14Q24322407-7A4428A9-0BA9-4981-B476-7C565EDDA895Q24322983-1A9E8EC3-5851-4E8B-BB91-1507FFAFBE32Q24529081-75733768-0352-4689-A56C-5170959DF3E1Q24530173-E73CF6ED-4B38-4A5D-8440-CBE45479AF47Q24537294-3B396631-7EE2-4055-86AD-961E9FBC0AE6Q24537559-B6597E9F-D384-44C9-94D8-458D87D024EFQ24547568-30FEC3A5-8B28-47BD-8229-C6E327DB662BQ24550851-BC72DBE3-5C68-4AD2-91BE-B4967368EE41Q24555816-6A874203-E6AA-4F20-BFE0-B8E92447FE6AQ24558689-23C58A73-C5A9-4EBF-AFAE-1CE00C4E89B4Q24654714-934CBE22-1870-40EB-9F35-BCB3E8FAFA7EQ24655274-F689F85F-0167-44D8-A593-10A1C0E6AED6Q24657375-83CD41B9-6C4C-4196-81E0-367B5053C62AQ24792628-032119D6-484C-4A9C-A741-A9672A5CF9B4Q24805570-E36DFA0B-A88C-44C8-9F5F-1533F967DCA3Q24806655-F6BF720C-31DE-45E0-B49A-25B5A3D7A5DFQ24816896-04079A85-F219-4E29-BB79-56379888E30DQ24817114-AAD820DA-FEAE-4CAF-8698-FD29C46656E7Q26740274-9B9D0962-7379-4FB2-8E39-EFBD04DF7EF6Q26744658-CB03DA17-EA79-4657-8D4F-857878E57021Q26751376-41DC00A6-B501-4E01-AD0C-DB2FE55A16C6Q26853718-61F9A0A3-1B0E-42C0-B9B2-ACFDF0B94CACQ27026783-6399212A-35C7-4E52-A736-4CEE06E182EEQ27477554-30151643-421B-41C7-A046-FE83C5A2658AQ27651007-776BC18D-8F24-4F03-93B2-C8F1A0FA90F5Q27676669-58B1D53A-6294-4F9A-BB7B-3EE2FE4171E7Q28139486-137F91C2-576B-40CC-844E-004920A1FF34Q28187852-19738C37-24AF-49E2-B574-076456BD9F2EQ28211408-447249CB-D39B-4B69-93B0-BC77DCF79C81Q28218885-DA0B2A82-E403-428F-AE82-B2201F7491DFQ28237281-6959FCDC-61A0-4687-A933-3476ED77EA81Q28269352-1DF5E727-BCD0-4F26-9A68-840B6168BD6FQ28281791-EBBD85AC-7EA7-40FA-A2A3-9055DE7288FBQ28508170-DB10D31E-A380-41E5-9FCF-266BCBD5B222
P2860
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The conserved SOCS box motif i ...... ins to proteasomal degradation
@ast
The conserved SOCS box motif i ...... ins to proteasomal degradation
@en
The conserved SOCS box motif i ...... ins to proteasomal degradation
@nl
type
label
The conserved SOCS box motif i ...... ins to proteasomal degradation
@ast
The conserved SOCS box motif i ...... ins to proteasomal degradation
@en
The conserved SOCS box motif i ...... ins to proteasomal degradation
@nl
prefLabel
The conserved SOCS box motif i ...... ins to proteasomal degradation
@ast
The conserved SOCS box motif i ...... ins to proteasomal degradation
@en
The conserved SOCS box motif i ...... ins to proteasomal degradation
@nl
P2093
P2860
P3181
P356
P1476
The conserved SOCS box motif i ...... ins to proteasomal degradation
@en
P2093
D J Hilton
G Hausmann
L M Zugaro
P2860
P304
P3181
P356
10.1073/PNAS.96.5.2071
P407
P50
P577
1999-03-02T00:00:00Z