Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins
about
Key role for ubiquitin protein modification in TGFβ signal transductionProlyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteinsProlyl isomerase Pin1 in cancerPhysiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway ModulationsOxidative Nanopatterning of Titanium Surface Influences mRNA and MicroRNA Expression in Human Alveolar Bone Osteoblastic CellsPin1 promotes transforming growth factor-beta-induced migration and invasion.Pin1 facilitates the phosphorylation-dependent ubiquitination of SF-1 to regulate gonadotropin beta-subunit gene transcriptionTranscription alterations of members of the ubiquitin-proteasome network in prostate carcinoma.Phosphorylation stabilizes Nanog by promoting its interaction with Pin1Crosstalk between nuclear factor I-C and transforming growth factor-β1 signaling regulates odontoblast differentiation and homeostasisProlyl isomerase Pin1 regulates mouse embryonic fibroblast differentiation into adipose cells.The roles of peptidyl-proline isomerases in gene regulation.Differential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signalingCurcumin and emodin down-regulate TGF-β signaling pathway in human cervical cancer cells.Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease.Smad phosphoisoform signaling specificity: the right place at the right timeProlyl isomerases in gene transcriptionActive Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancerPin1 protein regulates Smad protein signaling and pulmonary fibrosis.Inhibition of CDK-mediated phosphorylation of Smad3 results in decreased oncogenesis in triple negative breast cancer cells.Prolyl isomerase Pin1 downregulates tumor suppressor RUNX3 in breast cancer.Notch4-dependent antagonism of canonical TGF-β1 signaling defines unique temporal fluctuations of SMAD3 activity in sheared proximal tubular epithelial cells.Pin1-Nanog expression in human glioma is correlated with advanced tumor progression.Activin signaling as an emerging target for therapeutic interventionsThe role of PIN1 on odontogenic and adipogenic differentiation in human dental pulp stem cells.Role of Smads in TGFβ signaling.Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease.Regulation of the transforming growth factor β pathway by reversible ubiquitylation.Crosstalk between kinases and Nedd4 family ubiquitin ligases.Peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular disease.Epithelial-mesenchymal transition is regulated at post-transcriptional levels by transforming growth factor-β signaling during tumor progression.PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro ModelInhibition of CDK-mediated Smad3 phosphorylation reduces the Pin1-Smad3 interaction and aggressiveness of triple negative breast cancer cells.Pin1, the Master Orchestrator of Bone Cell Differentiation.The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target.TGF-β Signaling from Receptors to Smads.Pin1 is overexpressed and correlates with poor prognosis in gastric cancer.TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells.Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites.Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β.
P2860
023c57ed60932fd16120b8f43602ec163259578210246ed95becf5040036ec75c5dc6d2daa7ca7bb4533b3194e1bdc3588d93c547fa3231a9408376895c96753578a67ca9b923739bc03a2449d532dd0a62afd1f35e4810e35537cf19aea3559f3dbb0adc1b970158894a82faeb9af8b6d430432264ad8fcc9ccebde29801d5fdb5df594195f48268ad2dea3ea179f0b4a1564e5fb30525fdac46f0abf21a232fa51c42bfc689572869f7a1b75eec976d08d670b
P248
Q26824916-3D148999-F47A-43B7-8386-D8298878AE81Q26825421-3CF1CABF-06A1-4A57-B5DB-AEA66226B63CQ27024695-542D6F66-EB35-4D16-9EBE-893D3E4AF22BQ28079712-B212012D-5BAA-4286-BB80-D24E7BED9304Q28833552-37594FF3-38B4-4E59-83B0-86297DD414F6Q33581891-179C94E7-B0B4-4B79-8185-0AE8A79D1373Q33614048-352697FB-A6B4-44BC-9164-E80F51A78176Q33753890-3EDC61AE-D0E4-4D88-9312-C79905B62540Q34068097-E0A8A5ED-88E9-465E-9D01-A57C675A4A8AQ34110780-6ED90A73-8A24-4740-909F-E4D39F498E40Q34193004-27386E0F-1C25-40D3-A82E-7FB6FEB0E358Q34224274-F0709D8B-E715-4BD2-9436-3289374F9EE5Q34395698-325FA4FB-84ED-44EA-B158-79CEF51EA770Q34668705-2CD3C1F1-7ADB-4284-91FE-016AFA742198Q35194715-373DEBF6-ED44-4315-AA72-E728AFB4AB3FQ35478946-D012A8B0-53B9-48DC-93F7-BE24E71051C5Q35561852-B185A42E-ABB9-4B1B-83C9-96CEC14E8C2BQ35587470-5C89B6ED-34BF-4033-896E-F984C03DFE0CQ36078699-F0E61D76-7D8D-43F4-8305-FA79FF0907E4Q36187896-4B43ECDE-41C5-497E-9741-39503A93256EQ36223271-5FF58C71-B97B-4627-B30A-CAE2CA754A80Q37051481-2AAE984E-6E7A-4048-AFB8-0DC7D45B3F46Q37181702-46BC1134-E647-412B-90D7-A6C875BC87F6Q37268461-A1F06286-BBF0-4547-B53C-0215F4A0B06EQ37610703-85FC5BC8-2D07-40D0-A42E-B06ECCC3536EQ37885217-759B636B-5E04-4AFE-B340-84CDE9D46F33Q37891181-9204B151-2496-4120-8804-52F4B61C6C50Q38020840-856D85FD-947A-4BA4-9846-A201BE110AE3Q38181338-3E351CFC-593D-44EA-BDC0-607026A4243CQ38265843-C1EEB73E-B303-46BF-81D4-EC2CD9424BA8Q38349021-81B6B946-2818-4CF3-A47B-49E9BA778085Q38680458-43C4AA06-3F1A-4953-9968-9B5455ADA7B5Q38692982-EEAF144E-7874-4F24-A845-1E358B8EF576Q38844443-FD9AC0D3-DCFF-47AD-A62D-84296EB282AEQ38852028-AAC7830A-BEDB-4EA3-832B-3FCF20723BC6Q38906099-2DA94755-AE1F-42A2-BC49-67E394009B5DQ38950788-4C357DAA-8AD2-4B6B-A912-0FACD722E924Q39429575-77DF8B30-F345-4B38-8841-4390ECB22914Q41115192-AB06098F-C04C-4921-BE68-7E728AFD2DC4Q41468930-17CC51D5-47F0-412B-80B3-78937300DB11
P2860
Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Pin1 down-regulates transformi ...... g degradation of Smad proteins
@ast
Pin1 down-regulates transformi ...... g degradation of Smad proteins
@en
Pin1 down-regulates transformi ...... g degradation of Smad proteins
@en-gb
Pin1 down-regulates transformi ...... g degradation of Smad proteins
@nl
type
label
Pin1 down-regulates transformi ...... g degradation of Smad proteins
@ast
Pin1 down-regulates transformi ...... g degradation of Smad proteins
@en
Pin1 down-regulates transformi ...... g degradation of Smad proteins
@en-gb
Pin1 down-regulates transformi ...... g degradation of Smad proteins
@nl
prefLabel
Pin1 down-regulates transformi ...... g degradation of Smad proteins
@ast
Pin1 down-regulates transformi ...... g degradation of Smad proteins
@en
Pin1 down-regulates transformi ...... g degradation of Smad proteins
@en-gb
Pin1 down-regulates transformi ...... g degradation of Smad proteins
@nl
P2093
P2860
P921
P3181
P356
P1476
Pin1 down-regulates transformi ...... g degradation of Smad proteins
@en
P2093
Ayako Nakano
Daizo Koinuma
Hirotada Akiyama
Jun-ichi Hanai
Kohei Miyazono
Masahiro Abe
Masahiro Kawabata
Masao Saitoh
Takeshi Imamura
Toshio Matsumoto
P2860
P304
P3181
P356
10.1074/JBC.M804659200
P407
P577
2009-01-04T00:00:00Z